暴马子皮苯丙素类化学成分研究  

Study on Phenylpropanoids from the Stem Barks of Syringa reticulata

作　　者：郭爽[1] 刘艳[1] 管伟[1] 潘娟[1] 刘源[1] 杨炳友[1] GUO Shuang;LIU Yan;GUAN Wei;PAN Juan;LIU Yuan;YANG Bingyou(Heilongjiang University of Chinese Medicine, Harbin 150040, China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药信息》2021年第4期17-22,共6页Information on Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2018YFC1707100)。

摘　　要：目的:研究暴马子皮60%乙醇洗脱层的化学成分。方法:以70%乙醇提取暴马子皮,大孔树脂吸附法得到60%大孔树脂乙醇洗脱部位,经硅胶、ODS、凝胶和制备液相等方法进行分离纯化,根据理化性质,并通过NMR、MS等分析手段鉴定化合物结构。结果:从暴马子皮60%乙醇洗脱层中分离得到14个苯丙素类化合物,分别鉴定为alashinol B(1),橄榄树脂素-4′-O-β-D-葡萄糖苷(2),hyuganoside IIIa(3),橄榄树脂素-4-O-β-D-葡萄吡喃糖苷(4),(+)-cicloolivil(5),acteoside(6),(+)-pinoresinol-4-O-β-monoglycoside(7),sinapaldehydeglucoside(8),1,2-di-O-β-D-glucopranosyl-4-allylbenzene(9),shashenoside I(10),syringin(11),3,4,5-trihydroxy-allylbenzene,3-O-β-D-glucopyranosyl-4-O-β-D-glucopyranoside(12),caffeic acid(13),ferulic acid(14)。结论:化合物3、9、10、12首次从木犀科中分离得到,化合物5、6为首次从丁香属中分离得到,化合物1为首次从该植物中分离得到。Objective:To study the chemical constituents of the 60%ethanol elution layer of the stem barks of Syringa reticulata.Methods:The stem barks of Syringa reticulata was extracted by 70%ethanol,and the extraction of 60%ethanol fraction was obtained by using AB-8 macroporous resin as the adsorption material,then it was separated and purified by silica gel,ODS,Sephadex LH-20 and preparative HPLC.The structures of isolated compounds were established based on the physical and chemical means,NMR spectroscopy and high-resolution mass spectrometry(HR-ESI-MS).Results:14 compounds were isolated and identified as alashinol B(1),olivil-4′-O-β-D-glucoside(2),hyuganoside IIIa(3),olivil-4-O-β-D-glucoside(4),(+)-cicloolivil(5),acteoside(6),(+)-pinoresinol-4-O-β-monoglycoside(7),sinapaldehydeglucoside(8),1,2-di-O-β-D-glucopranosyl-4-allylbenzene(9),shashenoside I(10),syringin(11),3,4,5-trihydroxy-allylbenzene,3-O-β-D-glucopyranosyl-4-O-β-D-glucopyranoside(12),caffeic acid(13)and ferulic acid(14).Conclusion:Compounds 3,9,10 and 12 were isolated from the Oleaceae family for the first time,compounds 5 and 6 were isolated from the Syringa genus,and compound 1 was isolated from this plant for the first time.

关 键 词：暴马子皮 木犀科 化学成分 

分 类 号：R284[医药卫生—中药学]