疮疡Ⅰ号外敷对大鼠糖尿病性溃疡的影响  

Effect of External Application of Chuangyang I on Diabetic Ulcer Rats

作　　者：梁学威 苑海刚[1] 于天一[1] LIANG Xuewei;YUAN Haigang;YU Tianyi(Heilongjiang University of Chinese Medicine, Harbin 150040, China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药信息》2021年第4期37-41,共5页Information on Traditional Chinese Medicine

基　　金：黑龙江省博士后科研启动项目(LBH-Q20183);黑龙江中医药大学研究生创新科研项目(2019yjscx005)。

摘　　要：目的:观察疮疡Ⅰ号外敷对大鼠糖尿病性溃疡的影响。方法:SD大鼠30只,随机分为实验组、对照组和空白组。实验组、对照组建立糖尿病性溃疡模型,空白组不建模。实验组采用疮疡Ⅰ号外敷创面局部。于治疗第15天和第30天分别观察各组创面面积、临床炎症指标(hs-CRP)、创面局部促炎因子(TNF-α、IL-1β、IL-6和IL-18)、创面局部抑炎因子(IL-4、IL-10)、NF-κB-p65蛋白表达水平。结果:与对照组比较,实验组创面面积缩小、临床炎症指标降低、创面组织各项促炎因子水平下降、创面组织各项抑炎因子水平升高、创面NF-κB-p65蛋白表达水平下降(P<0.05)。结论:疮疡Ⅰ号治疗糖尿病性溃疡机制可能与抑制NF-κB信号通路,降低促炎因子水平,升高抑炎因子水平,进而抑制组织炎症有关。Objective:To observe the effect of external application of Chuangyang I on diabetic ulcer in rats.Methods:30 SD rats were randomly divided into the study group,the control group and the blank group.Diabetic ulcer model was established in the study group and in the control group.The study group was treated with external application of Chuangyang I.The wound area was measured,the clinical inflammatory index(hs-CRP),the local pro-inflammatory factors(TNF-α,IL-1β,IL-6 and IL-18),local anti-inflammatory factors(IL-4,IL-10)and NF-κb-p65 protein levels were observed after 15 and 30 days of the treatment respectively.Results:Compared to those in the control group,the wound areas were reduced,clinical inflammation indexes and various pro-inflammatory factors were decreased,anti-inflammatory factors were increased,and the protein expression of NF-κb-p65 in wound tissue was decreased in the study group(P<0.05).Conclusion:It is suggested that the mechanism of the treatment of diabetic ulcer with Chuangyang I may be related to the inhibition of NF-κB signaling pathway,thus reducing the level of pro-inflammatory factors,increasing the level of anti-inflammatory factors,and then inhibiting tissue inflammation.

关 键 词：糖尿病性溃疡 外敷 疮疡Ⅰ号 NF-ΚB 

分 类 号：R285.5[医药卫生—中药学]