白脂素与2型糖尿病及其血管并发症的研究进展  

Research progress of asprosin in type 2 diabetes mellitus and its vascular complications

作　　者：沙宇菁 李彦彦 杨玲[1] Sha Yujing;Li Yanyan;Yang Ling(Department of Endocrinology,Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China)

机构地区：[1]江苏大学附属医院内分泌代谢科,镇江212000

出　　处：《国际内分泌代谢杂志》2021年第2期133-137,共5页International Journal of Endocrinology and Metabolism

基　　金：江苏省预防医学科研课题(Y2018109)。

摘　　要：白脂素(asprosin)是一种新型葡萄糖调控蛋白激素,其主要由白色脂肪细胞合成分泌。Asprosin可通过增强胰岛素抵抗、调节胰岛素分泌、影响食欲参与糖脂代谢,从而调节血糖稳态。此外,研究发现Asprosin与糖尿病大血管并发症及糖尿病微血管并发症存在较多联系,但具体机制尚不清楚。深入探讨Asprosin与糖尿病及其血管并发症的作用机制,可为糖尿病及其血管并发症的治疗提供新靶点。Asprosin is a new type of glucose regulatory protein hormone,which is mainly synthesized and secreted by white adipocytes.Asprosin can regulate glucose homeostasis by enhancing insulin resistance,regulating insulin secretion and affecting appetite.In addition,studies have found that asprosin is associated with diabetic macrovascular complications and diabetic microvascular complications,but the specific mechanism is not clear.In order to provide a new target for the treatment of diabetes mellitus and its vascular complications,the mechanism of asprosin in diabetes mellitus and its vascular complications should be explored.

关 键 词：白脂素 2型糖尿病 糖尿病大血管并发症 糖尿病微血管并发症 

分 类 号：R587.2[医药卫生—内分泌]