Proton linac-based therapy facility for ultra-high dose rate (FLASH) treatment  

作　　者：Wen-Cheng Fang Xiao-Xia Huang Jian-Hao Tan Chao-Peng Wang Cheng-Cheng Xiao Yi-Xing Lu Yu Zhang Yu-Qing Yang Yi-Ming Xu Han-Yu Gong Jun-Qiang Zhang Shao-Peng Zhong Zhen-Tang Zhao 

机构地区：[1]Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201204,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Shanghai APACTRON Particle Equipment Company Limited,Shanghai 201800,China [4]Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China

出　　处：《Nuclear Science and Techniques》2021年第4期1-9,共9页核技术（英文）

基　　金：This work was supported by the Alliance of International Science Organizations(No.ANSO-CR-KP-2020-16);the National Key R&D Program of China(No.2018YFF0109203).

摘　　要：As an advanced treatment method in the past five years,ultra-high dose rate(FLASH)radiotherapy as a breakthrough and milestone in radiotherapy development has been verified to be much less harmful to healthy tissues in different experiments.FLASH treatments require an instantaneous dose rate as high as hundreds of grays per second to complete the treatment in less than 100 ms.Current proton therapy facilities with the spread-out of the Bragg peak formed by different energy layers,to our knowledge,cannot easily achieve an adequate dose rate for FLASH treatments because the energy layer switch or gantry rotation of current facilities requires a few seconds,which is relatively long.A new design for a therapy facility based on a proton linear accelerator(linac)for FLASH treatment is proposed herein.It is designed under two criteria:no mechanical motion and no magnetic field variation.The new therapy facility can achieve an ultrahigh dose rate of up to 300 Gy/s;however,it delivers an instantaneous dose of 30 Gy within 100 ms to complete a typical FLASH treatment.The design includes a compact proton linac with permanent magnets,a fast beam kicker in both azimuth and elevation angles,a fixed gantry with a static superconducting coil to steer proton bunches with all energy,a fast beam scanner using radio-frequency(RF)deflectors,and a fast low-level RF system.All relevant principles and conceptual proposals are presented herein.

关 键 词：Proton therapy FLASH Proton linac DEFLECTOR Superconducting coil Fast scanner 

分 类 号：TH77[机械工程—仪器科学与技术]