Analysis of influencing factors on the method for determining boron concentration and dose through dual prompt gamma detection  

作　　者：Feng Tian Chang-Ran Geng Xiao-Bin Tang Di-Yun Shu Huang-Feng Ye Silva Bortolussi Chun-Hui Gong 

机构地区：[1]Department of Nuclear Science and Technology,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,China [2]Key Laboratory of Nuclear Technology Application and Radiation Protection in Astronautics(Nanjing University of Aeronautics and Astronautics),Ministry of Industry and Information Technology,Nanjing 210016,China [3]Unit of Pavia,National Institute of Nuclear Physics(INFN),Via A.Bassi 6,27100 Pavia,Italy

出　　处：《Nuclear Science and Techniques》2021年第4期10-19,共10页核技术（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.11805100 and 11905106);the Fundamental Research Funds for the Central Universities(No.NG2020003).

摘　　要：A method based on the cross-sectional relationship between^(10)B(n,α)^(7)Li and^(1)H(n,γ)^(2)H was proposed to detect and reconstruct the three-dimensional boron concentration/dose distribution in vivo during boron neutron capture therapy(BNCT).Factors such as the neutron energy,fluence rate,and degree of non-uniform distribution of the boron concentration in a voxel may affect the results of this method.A theoretical analysis of the accuracy of the method using a Monte Carlo simulation shows that the determining error is generally less than 1%under different tumor locations and neutron source configurations.When the voxel size is larger than 0.4 cm,the determining error might be higher for a non-uniformly distributed boron concentration in the voxel because of the changes in the neutron energy and fluence rate.In conclusion,the proposed method enables an accurate threedimensional boron determination in vivo during BNCT.

关 键 词：BNCT Boron concentration Prompt gamma Capture cross section 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]