社区老年人糖尿病和高血压患病情况与轻度认知障碍的关联性研究  

The association analysis of concurrent diabetes and hypertension with mild cognitive impairment in community-dwelling older adults

作　　者：甘旭光 刘丹[1,2] 程桂荣[1,2] 张波[1,2] 安丽娜 吴玉莲[1,2] 曾燕 GAN Xu-guang;LIU Dan;CHENG Gui-rong;ZHANG Bo;AN Li-na;WU Yu-lian;ZENG Yan(Medical School of Wuhan University of Science and Technology,Wuhan,Hubei 430065,China)

机构地区：[1]武汉科技大学医学院,湖北430065 [2]武汉科技大学先进技术研究院

出　　处：《现代预防医学》2021年第7期1202-1205,1214,共5页Modern Preventive Medicine

基　　金：国家重点研发计划(2020YFC200600);国家自然科学基金(71774127)。

摘　　要：目的探讨糖尿病共患高血压与社区老年人轻度认知障碍(Mild cognitive impairment, MCI)的关系,为社区认知障碍防控提供科学依据。方法数据来源于湖北老年记忆队列(注册号:ChiCTR1800019164)第一轮基线调查。对参与者进行问卷调查、身体测量和神经心理评估,根据糖尿病和高血压患病情况将参与者分成四组:不患病组、糖尿病组、高血压组和糖尿病共患高血压组。采用多因素logistic回归分析不同患病组与MCI的关系。结果共纳入3 011人,年龄范围为65~92岁(平均年龄70.93±5.24岁),MCI患病率为17.9%(16.5%~19.2%)。组间两两比较结果显示:糖尿病组、高血压组和糖尿病共患高血压组MCI的患病率均高于不患病组(21.9%、19.1%、23.8%vs 14.7%),差异具有统计学意义(P<0.05)。调整性别、年龄、文化程度、婚姻状况、吸烟、饮酒、体育锻炼、智力活动、BMI、收缩压、舒张压后,糖尿病组、高血压组和糖尿病共患高血压组MCI的患病风险分别是不患病组的1.53(1.09~2.14)、1.32(1.02~1.54)和1.79(1.23~2.32)倍。结论 MCI患病率在糖尿病、高血压和糖尿病共患高血压人群中均增高,且在糖尿病共患高血压人群中具有更高的患病风险,科学管理糖尿病和高血压,阻止共病的发生,有利于MCI的预防。Objective To analyze the association of concurrent diabetes and hypertension with mild cognitive impairment(MCI) in community-dwelling older adults, and to provide scientific evidence for the prevention and control of MCI in the community. Methods Cross-sectional data was collected from the first round of baseline survey of Hubei Aging And Memory Cohort Study(HAMCS),(Registration Number: ChiCTR180019164). Eligible participants received questionnaire survey, physical measurement and neuropsychological testing. All subjects were divided into 4 groups based on the diagnose of comorbidity: Non-disease group, Diabetes group, Hypertension group and Concurrent Diabetes and Hypertension group. Multivariate logistic regression analysis was used to analyze the association between different groups and MCI. Results A total of 3 011 participants aged 65 and older were included, with an age range of 65-92 years(average age was 70.93±5.24 years). The overall prevalence of MCI was 17.9%(16.5%-19.2%). Pairwise comparisons between groups showed that the prevalence of MCI in diabetes group, hypertension group and concurrent diabetes and hypertension group were higher than that in non-disease group(21.9%,19.1%,23.8% vs 14.7%, P<0.05). After adjusting for gender, age, education level, marital status, smoking, drinking, physical exercise, intellectual activity, BMI, systolic blood pressure and diastolic blood pressure, compared with non-disease group, diabetes, hypertension and concurrent diabetes and hypertension group were significantly associated with a higher risk of MCI, with OR values of 1.53(1.09-2.14), 1.32(1.02-1.54) and 1.79(1.23-2.32), respectively. Conclusion Diabetes, hypertension and concurrent diabetes and hypertension are associated with higher prevalence of MCI in community-dwelling older adults, and there is a notable higher risk of MCI among people with concurrent diabetes and hypertension. Successful management of diabetes and hypertension and prevention of comorbidity are in favor of prevention of the occurrenceo

关 键 词：糖尿病共患高血压 轻度认知障碍 患病率 社区老年人 

分 类 号：R161.7[医药卫生—公共卫生与预防医学] R587.1