某肿瘤医院儿童血液病患者TORCH感染状况研究  

Prevalence of TORCH infection in hospitalized children with hematological diseases in a cancer hospital

作　　者：张倩[1] 陈少华[1] 孙永梅 陈兆武 李明[1] ZHANG Qian;CHEN Shao-hua;SUN Yong-mei;CHEN Zhao-wu;LI Ming(Department of Clinical laboratory,The First Affiliated Hospital of University of Science and Technology of China,Hefei 233004,Anhui Province,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)检验科,安徽合肥233004

出　　处：《热带病与寄生虫学》2021年第2期70-73,共4页Journal of Tropical Diseases and Parasitology

基　　金：中央高校基本科研业务费专项资金资助(WK9110000026)。

摘　　要：目的研究中国科学技术大学附属第一医院西区(安徽省肿瘤医院)儿童血液病患者TORCH感染的状况。方法选取2015年11月—2019年7月在该院儿血科住院的354例患儿为研究对象,采用化学发光免疫测定仪检测患儿血TORCH的IgG、IgM抗体,分析354例患儿TORCH感染模式、年龄和疾病分布状况。结果弓形虫(TOX)、风疹病毒(RV)、巨细胞病毒(CMV) IgM阳性率分别为0.6%、4.2%和7.3%;TOX、RV、CMV、单纯疱疹病毒(HSV-Ⅰ、HSV-Ⅱ)的IgG阳性率分别为21.2%、88.1%、91.2%、49.2%、15.8%。合并感染1例,为CMV和RV合并感染。不同年龄段儿童RV-IgM、CMV-IgM、RV-IgG、HSV-Ⅰ-IgG和HSV-Ⅱ-IgG阳性率差异有统计学意义。卡方趋势检验结果显示,RV-IgM、CMV-IgM和HSV-Ⅱ-IgG阳性率随着患儿年龄增加而下降,RV-IgG和HSV-Ⅰ-IgG阳性率随患儿年龄增加而上升。不同疾病类型的患儿,其TOX-IgG、HSV-Ⅰ-IgG、HSV-Ⅱ-IgG阳性率差异有统计学意义。结论对血液病患儿开展TORCH血清学检测,可明确其感染类型和既往感染情况,为血液病的诊断和治疗提供帮助。Objective To investigate the status of TORCH infection in children with hematological diseases in the First Affiliated Hospital of USTC(Western District),Anhui Provincial Cancer Hospital.Methods 354 children treated in the Department of Pediatric Hematology of our hospital were included from November 2015 to July 2019.Blood samples were obtained from all children,and detected for the TORCH-IgG and IgM using chemiluminescence immunoassay.Then the TORCH infection pattern,age distribution and disease types were analyzed in the 354 patients.Results TORCH test showed that the positive rate was 0.6%,4.2%and 7.3%for Toxoplasma-immunoglobulin M(TOX-IgM),rubella virus-IgM(RV-IgM)and cytomegalovirus-IgM(CMV-IgM),and 21.2%,88.1%,91.2%,49.2%and 15.8%for TOX-IgG,RV-IgG,CMV-IgG,HSV-Ⅰ-IgG and HSV-Ⅱ-IgG,respectively.Co-infection of CMV+RV occurred in one child.The infection rate of RV-IgM(+),CMV-IgM(+),RV-IgG(+),HSV-Ⅰ-IgG(+)or HSV-Ⅱ-IgG(+)was significantly different in different age group.Chi square trend test showed that the positive rates of RV-IgM,CMV-IgM and HSV-Ⅱ-IgG decreased with the age of children,while the positive rates of RV-IgG and HSV-Ⅰ-IgG increased with the age of children.The positive rate of TOX-IgG,HSV-Ⅰ-IgG and HSV-Ⅱ-IgG was significantly different in children with diverse type of infection.Conclusion TORCH-IgG and IgM detection in children with hematological diseases can identify the type of infection and previous infection,and provide help for the diagnosis and treatment of hematological diseases.

关 键 词：TORCH感染 儿童血液病 刚地弓形虫 风疹病毒 巨细胞病毒 单纯疱疹病毒 

分 类 号：R725.1[医药卫生—儿科] R725.3[医药卫生—临床医学]