日本血吸虫与曼氏血吸虫的致病差异  

Difference of pathology induced by Schistosoma japonicum and Schistosoma mansoni

作　　者：陈舒心 秦铭 周方斌 何兴 CHEN Shu-xin;QIN Ming;ZHOU Fang-bin;HE Xing(Department of Tropical Medicine,Navy Medical University,Shanghai 200433,China.)

机构地区：[1]海军军医大学热带病学教研室,上海200433

出　　处：《热带病与寄生虫学》2021年第2期112-115,F0003,共5页Journal of Tropical Diseases and Parasitology

基　　金：上海市卫生健康委员会科研项目面上课题(201740099)。

摘　　要：曼氏血吸虫和日本血吸虫是全球范围内两种主要的肠道血吸虫病病原体,所致基本病理均为虫卵引起的肝脏肉芽肿和纤维化,但两者在产卵方式以及肉芽肿的组成细胞等方面均存在明显差异。目前,我国的血吸虫病研究主要以日本血吸虫病为对象,国外主要以曼氏血吸虫病为对象,而介绍两种血吸虫致病差异的综述较少。为更好地理解两种血吸虫的致病差异,本文从血吸虫的基因组和进化路径、幼虫迁移、成虫寄生位置及产卵方式、局部组织病理、肉芽肿的形成机制以及肉芽肿的细胞组成等6个方面对日本血吸虫和曼氏血吸虫的致病差异进行了综述。Schistosoma mansoni and Schistosoma japonica are two major pathogens of intestinal schistosomiasis worldwide.Primary pathology of the infection involved in these two parasites is designated by the egg-induced liver granuloma and fibrosis,yet the difference is significant in oviposition mode and constituent cells of the granuloma between the two infections.At present,Schistosoma japonicum is the major study interest in China,whereas Schistosoma mansoni is intensively investigated in foreign countries,and few reviews are available on the differences between the two kinds of schistosomiasis.In order to better understand the pathology diversity between Schistosoma japonicum and Schistosoma mansoni infection,this paper reviewed the pathological differences of the two parasites from six aspects,including the genome and evolutionary pathway of Schistosoma,larval migration,parasitic location and oviposition mode of adults,local histopathological findings,mechanisms of granulomatous formation and cell composition.

关 键 词：日本血吸虫 曼氏血吸虫 虫卵肉芽肿 致病差异 

分 类 号：R532.21[医药卫生—内科学]