不同抗生素应用方式治疗重型颅脑损伤继发颅内感染的临床效果及不良反应探讨  

Discussion on the Clinical Effects and Adverse Reactions of Different Antibiotic Application Methods in the Treatment of Severe Craniocerebral Injury Secondary to Intracranial Infection

作　　者：黄伟[1] 张德启[1] 刘晓华[2] HUANG Wei;ZHANG De-qi;LIU Xiao-hua(Department of Neurosurgery,Changyi City People's Hospital,Shandong Province,261300 China;Department of Neurology,Changyi City People's Hospital,Shandong Province,261300 China)

机构地区：[1]山东昌邑市人民医院神经外科,山东昌邑261300 [2]山东昌邑市人民医院神经内科,山东昌邑261300

出　　处：《系统医学》2021年第5期88-90,共3页Systems Medicine

摘　　要：目的探讨不同抗生素应用方式治疗重型颅脑损伤继发颅内感染的临床效果及不良反应。方法选择该院2018年11月—2019年11月期间收治的重型颅脑损伤继发颅内感染患者98例,采用计算机随机分两组,对照组49例患者采用抗生素全身静脉滴注治疗方式,观察组49例患者实施抗生素鞘内注射治疗方式,对其临床效果及不良反应进行观察分析。结果观察组治疗时间、退热时间及白细胞计数恢复正常的时间均短于对照组,同时观察组不良反应发生率6.12%与对照组不良反应发生率20.41%相比有一定程度的下降,差异有统计学意义(χ^(2)=4.346,P=0.037),观察组治疗有效率95.92%与对照组治疗有效率73.47%相比有所上升,差异有统计学意义(χ^(2)=9.525,P=0.002)。结论抗生素鞘内注射抗生素相比全身静脉滴注应用方式治疗重型颅脑损伤继发颅内感染的临床效果明显更佳,在短时间内改善患者的临床表现、体征等,治愈时间明显缩减,降低不良反应,促进患者早日康复,从而减轻家庭压力。Objective To explore the clinical effects and adverse reactions of different antibiotic applications in the treatment of intracranial infections secondary to severe head injury.Methods A total of 98 patients with severe craniocerebral injury secondary to intracranial infection admitted to the hospital from November 2018 to November 2019 were selected and randomly divided into 2 groups by computer.49 patients in the control group were treated by systemic intravenous infusion of antibiotics.49 patients in the observation group received intrathecal injection of antibiotics,and their clinical effects and adverse reactions were observed and analyzed.Results The treatment time,antipyretic time and white blood cell count recovery time of the observation group were shorter than those of the control group.At the same time,the incidence of adverse reactions in the observation group was 6.12% compared with the 20.41% in the control group,which decreased to a certain extent,the difference was statistically significant(χ^(2)=4.346,P=0.037),the treatment effective rate of 95.92% in the observation group increased compared with the treatment effective rate of 73.47% in the control group,the difference was statistically significant(χ^(2)=9.525,P=0.002).Conclusion Intrathecal injection of antibiotics has significantly better clinical effects than systemic intravenous drip in the treatment of intracranial infections secondary to severe head injury.It can improve the clinical manifestations and physical signs of patients in a short period of time,and the cure time is significantly reduced and adverse reactions were decreased,which can promote the patient's early recovery,thereby reducing family pressure.

关 键 词：不同抗生素应用方式 重型颅脑损伤 继发颅内感染 临床效果 不良反应 

分 类 号：R651[医药卫生—外科学]