原子吸收光谱法测定丙戊酸钠缓释片中钠的改进  

Modification on Atomic Absorption Spectrometric Method for Determination of Sodium in Sodium Valproate Sustained-release Tablets

作　　者：吴甫琛 谢演晖[1] Wu Fuchen;Xie Yanhui(Guangzhou Institute for drug control,Guangzhou,Guangdong 510160,China)

机构地区：[1]广州市药品检验所,广东广州510160

出　　处：《北方药学》2020年第12期12-13,共2页Journal of North Pharmacy

摘　　要：目的:改进火焰原子吸收光谱法测定丙戊酸钠缓释片中的钠,使钠的含量测定更加简便和准确。方法:样品经过湿法消解,在330.3nm波长下测定钠含量。结果:钠在0~100μg/mL浓度范围内线性关系良好,相关系数r=0.9997;该方法精密度高,重现性好,平均回收率为100.2%(n=9);RSD为0.7%。结论:改进后的方法准确、简便,能更好地控制丙戊酸钠缓释片中的钠含量。Objective Improve a method for determination of Na in Sodium Valproate Sustained-release Tablets by FAAS and makes the determination of Na more simple and accurate.Methods Samples were digested by nitrification.Determination of Na by FAAS at 330.3nm wavelength.Results The method displayed a good linearity for Na between 0 and 100μg/mL,the correlation coefficient was 0.9997.The method had good precision and repeatable.The average recoveries(n=9)were 100.2%,RSD was 0.7%.Conslusion The improved method is accurate,sensitive and more suitable for the determination of Na in Sodium Valproate Sustained-release Tablets.

关 键 词：原子吸收光谱法 丙戊酸钠缓释片 钠 

分 类 号：R927.2[医药卫生—药学]