雷公藤红素参与脂质代谢调控的研究进展  

Research Progress of Celastrol in Regulation of Lipid Metabolism

作　　者：周永强 周维[1] 岳兰昕 邓慧芳 邱丽珍 倪毓浩 高月[1] ZHOU Yongqiang;ZHOU Wei;YUE Lanxin;DENG Huifang;QIU Lizhen;NI Yuhao;GAO Yue(Anti-radiation Drug Research Laboratory,Institute of Radiation Medicine,Academy of Military Medical Sciences of PLA,Beijing 100850,China)

机构地区：[1]中国人民解放军军事医学研究院辐射医学研究所抗辐射药物研究室,北京100850

出　　处：《医药导报》2021年第5期587-592,共6页Herald of Medicine

摘　　要：雷公藤红素是源于雷公藤根部的重要活性成分,在促进脂质消耗、控制体质量等方面拥有独特效果,被公认为是最有潜力的减肥活性成分。该文综述雷公藤红素参与机体脂质代谢的国内外相关研究最新进展,从瘦素敏感性、胰岛素抵抗、脂肪细胞分化、线粒体功能、炎性控制以及肠道微生态等方面,系统阐述雷公藤红素调控机体脂质代谢及相关分子生物学机制,为促进基于雷公藤红素代谢药物的研发提供科学参考。Celastrol,extracted from the root of Tripterygium wilfordii,has been recognized as the most potential anti-obesity active component for its unique effects on the regulation of body weight and lipid metabolism.Based on the latest studies on celastrol all over the world,this paper reviews the role of celastrol in the regulation of lipid metabolism and provides a summary of the molecular mechanisms,including increasing the sensitivity to leptin receptors,inhibiting insulin resistance,increasing energy consumption in mitochondria,suppressing the differentiation of adipocytes,improving intestinal microecology,and anti-inflammatory effects;aiming to provide scientific references to the research and development of metabolic drugs based on celastrol.

关 键 词：雷公藤红素 脂质代谢 肥胖 胰岛素抵抗 瘦素 

分 类 号：R282.71[医药卫生—中药学] R285[医药卫生—中医学]