雷公藤毒性的历史认识与评价  

Historical Cognition and Evaluation of Tripterygium Wilfordii Toxicity

作　　者：任利文 郑湘锦 李婉[1] 王金华[1] 杜冠华[1] REN Liwen;ZHENG Xiangjin;LI Wan;WANG Jinhua;DU Guanhua(The State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Key Laboratory of Drug Target Research and Drug Screen,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]药物靶点研究与新药筛选北京市重点实验室,中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《医药导报》2021年第5期637-641,共5页Herald of Medicine

基　　金：中国医学科学院协同创新工程(2016-I2M-3-007);国家科技部十三五重大新药创制(2018ZX09711001-005-025)。

摘　　要：雷公藤是临床常用治疗自身免疫性疾病的一味中药,其毒副反应严重,甚至引发患者死亡。该文通过总结历代典籍对雷公藤毒性的记载,结合现代研究,从毒性反应的临床表现、物质基础、分子机制及减毒策略等方面,评价雷公藤毒性反应与药效活性的关系,以期为雷公藤的科学认识及合理使用提供参考。Tripterygium wilfordii is a common traditional Chinese medicine used in the treatment of autoimmune diseases,which has serious toxicity and side effects,and even causes death.In the article,we summarized the toxic components,molecular mechanisms,clinical manifestations and strategy for reducing toxicity of Tripterygium wilfordii,from the records in historical and modern literatures,which might provide guidance for the rational use of Tripterygium wilfordii.

关 键 词：雷公藤 药理活性 毒性 分子机制 减毒策略 

分 类 号：R282.71[医药卫生—中药学] R969.3[医药卫生—中医学]