3例氯氮平治疗精神分裂症的药学监护  

Pharmaceutical Care in 3 Patients with Schizophrenia Treated with Clozapine

作　　者：林芝 卜琴芳[1] 李宁[1] 陈方斌[1] 陈颖[1] 吴晓燕[1] 瞿发林[1] LIN Zhi;BU Qinfang;LI Ning;CHEN Fangbin;CHEN Ying;WU Xiaoyan;QU Falin(Department of Pharmacy,904 th Hospital of Joint Logistics Support Force of People's Liberation Army,Changzhou 213003,China)

机构地区：[1]中国人民解放军联勤保障部队第九○四医院药剂科,常州213003

出　　处：《医药导报》2021年第5期674-677,共4页Herald of Medicine

基　　金：全军医药卫生科研基金课题(14ZX04);2017年度江苏省药学会-奥赛康医院药学基金资助项目(A201735)。

摘　　要：目的探讨临床药师在精神分裂症患者服用氯氮平治疗期间的药学监护作用。方法基于血药浓度监测、代谢酶基因多态性检测等方法,临床药师对3例精神分裂症患者口服氯氮平期间发生的不良反应、与药物间的相互作用、与食物间的相互作用进行药学监护。结果临床药师协助医师有效解决临床在使用氯氮平过程中遇到的疑难问题,使用药个体化,同时对患者的用药过程进行监测,发现、防止和解决与用药有关的问题,确保患者用药安全。结论药学监护在精神分裂症的长期维持治疗中发挥了重要作用。Objective To evaluate the effect of pharmaceutical care provided by clinical pharmacists in schizophrenia patients treated with clozapine.Methods Clinical pharmacists provided pharmaceutical care for 3 patients with schizophrenia during their oral administration of clozapine.The adverse reactions,drug-drug interactions and drug-food interactions were monitored by methods of therapeutic drug monitoring,and gene polymorphism detection of metabolic enzymes.Results Clinical pharmacists assisted doctors in solving the difficult problems in the clinical use of clozapine,scheming the individualized drug treatment,and monitoring the patient's medication process.Pharmaceutical care helped to find,prevent and solve problems related to medication,to ensure the patient's medication safety.Conclusion Pharmaceutical care played an important role in long-term maintenance treatment of schizophrenia.

关 键 词：氯氮平 精神分裂症 药学监护 

分 类 号：R971.41[医药卫生—药品] R969.3[医药卫生—药学]