HCV相关肝细胞癌组织内HCV RNA及核心蛋白水平表达研究  

The research of the expression of HCV RNA and core protein in the tissues of HCV-related hepatocellular carcinoma with bile duct tumor thrombus

作　　者：张波[1] 张余芬 ZHANG Bo;ZHANG Yu-fen(Department of Hepatology,The Fifth People′s Hospital of Wuxi,Wuxi 214000,Jiangsu,China)

机构地区：[1]无锡市第五人民医院肝病科,江苏214000

出　　处：《肝脏》2021年第2期179-181,共3页Chinese Hepatology

基　　金：2018年无锡市科协软科学研究课题(KX-18-B10)。

摘　　要：目的研究丙型肝炎病毒(HCV)相关肝细胞癌组织内HCV RNA及核心蛋白表达的临床意义。方法纳入54例HCV相关肝细胞癌患者作为研究对象,检测HCV相关肝细胞癌癌组织和癌旁组织HCV RNA与HCV核心蛋白阳性率,比较癌组织与癌旁组织HCV RNA及HCV核心蛋白阳性率。比较不同分期、分化程度患者癌组织HCV RNA和HCV核心蛋白阳性率。结果癌组织与癌旁组织HCV RNA阳性率差异有统计学意义(P<0.05)。癌组织与癌旁组织HCV核心蛋白阳性率比较,差异显著(P<0.05)。HCV相关肝细胞癌癌组织内HCV RNA阳性率与HCV核心蛋白阳性率分布具有良好的一致性(Kappa值=0.951,P=0.000)。不同病理分期癌组织HCV RNA阳性率差异显著(P<0.05)。不同分化程度癌组织HCV RNA阳性率差异显著(P<0.05)。不同分期患者HCV核心蛋白阳性率差异显著(P<0.05)。不同分化程度癌组织HCV核心蛋白阳性率差异显著(P<0.05)。结论HCV RNA及核心蛋白阳性率与HCV相关肝细胞癌发生相关,监测HCV RNA含量与HCV核心蛋白有助于HCV相关肝细胞癌的诊疗。Objective To study the clinical significance of the expression of hepatitis C virus(HCV)RNA and core protein in the tissues of hepatitis C virus(HCV)-related hepatocellular carcinoma.Methods Fifty-four patients of HCV-related hepatocellular carcinoma were included as the research subjects,the positive rates of HCV RNA and HCV core protein in the patients of HCV-related hepatocellular carcinoma of cancer tissue and paracancerous tissue were detected.The positive rates of HCV RNA and HCV core protein between cancer and adjacent tissues were compared,the positive rates of HCV RNA and HCV core protein in cancer tissues of patients with different stages and differentiation were compared.Results There was significant difference in the positive rate of HCV RNA between cancer tissue and adjacent tissue(P<0.05).There was significant difference in the positive rate of HCV core protein between cancer tissue and adjacent tissue(P<0.05).The distribution of HCV RNA positive rate and HCV core protein positive rate in the patients of HCV related hepatocellular carcinoma was consistent(Kappa value=0.951,P=0.000).The positive rate of HCV RNA was significantly different in different pathological stages(P<0.05).The positive rate of HCV RNA in different differentiated cancer tissues was significantly different(P<0.05).The positive rate of HCV core protein was significantly different in different stages(P<0.05).The positive rate of HCV core protein in different differentiated cancer tissues was significantly different(P<0.05).Conclusion The positive rate of HCV RNA and core protein are related to the occurrence of HCV-related hepatocellular carcinoma.It is helpful to the diagnosis and treatment of HCV-related hepatocellular carcinoma by monitoring the content of HCV RNA and core protein.

关 键 词：HCV相关肝细胞癌 癌组织 HCV RNA 核心蛋白 

分 类 号：R51[医药卫生—内科学]