环己磺菌胺的合成新路线研究  

Novel Synthetic Route of Chesulfamide

作　　者：冯姝尧 江晓敏 颜芊 李江胜 FENG Shu-yao;JIANG Xiao-min;YAN Qian;LI Jiang-sheng(School of Chemistry and Food Engineering,Changsha University of Science&Technology,Changsha 410117,China)

机构地区：[1]长沙理工大学化学与食品工程学院,湖南长沙410117

出　　处：《精细化工中间体》2021年第1期5-7,共3页Fine Chemical Intermediates

基　　金：国家重点研发计划资助项目(2017YFB0307200);国家级大学生创新创业训练计划项目(202010536017)。

摘　　要：以2-氯环己酮为原料,经亲核磺化、氯化和胺化3步反应合成了环己磺菌胺,总收率55.6%。中间体2-氧代环己基磺酸钠和环己磺菌胺的结构经核磁共振氢谱和碳谱确证。该工艺方法操作简单,反应条件温和。Chesulfamide was obtained with a total yield of 55.6%through sequential nucleophilic sulfonylation,chloronation and amination of 2-chlorocyclohexanone.The structures of sodium 2-oxocyclohexane-1-sulfonate as a key intermediate and chesulamide were confirmed by IR,^(1)H and ^(13)C NMR spectra.This new process has advantages including easy operation and mild conditions.

关 键 词：环己磺菌胺 2-氯环己酮 磺化 胺化 

分 类 号：O623.626[理学—有机化学]