Structure of intact human MCU supercomplex with the auxiliary MICU subunits  

作　　者：Wei Zhuo Heng Zhou Runyu Guo Jingbo Yi Laixing Zhang Lei Yu Yinqiang Sui Wenwen Zeng Peiyi Wang Maojun Yang 

机构地区：[1]Ministry of Education Key Laboratory of Protein Science,Tsinghua-Peking Joint Center for Life Sciences,Beijing Advanced Innovation Center for Structural Biology,School of Life Sciences,Tsinghua University,Beijing 100084,China [2]Institute for Immunology and School of Medicine,Tsinghua-Peking Center for Life Sciences,Tsinghua University,Beijing 100084,China [3]Beijing Key Laboratory for Immunological Research on Chronic Diseases,Tsinghua University,Beijing 100084,China [4]Cryo-EM Facility Center,Southern University of Science Technology,Shenzhen 518055,China

出　　处：《Protein & Cell》2021年第3期220-229,共10页蛋白质与细胞（英文版）

摘　　要：Dear Editor,Mitochondrial Ca2+homeostasis regulates energy production,cell division,and cell death.The basic properties of mitochondrial Ca2+uptake have been firmly established.The Ca2+influx is mediated by MCU,driven by membrane potential and using a uniporter mechanism(Vasington and Murphy,1962).Patch-clamp analysis of MCU currents demonstrated that MCU is a channel with exceptionally high Ca2+selectivity(Kirichok et al.,2004).

关 键 词：MCU Patch AUXILIARY 

分 类 号：Q244[生物学—细胞生物学]