糖尿病性周围神经病变和VD3水平的相关性分析  

The Correlation Between Type 2 Diabetic Peripheral Neuropathy and Serum 25(OH)Vitamin D3 Level

作　　者：张金卉 王春艳 ZHANG Jinhui;WANG Chunyan(General Aviation Hospital of Chaoyang District, Beijing 100000, China)

机构地区：[1]北京市朝阳区航空总医院,北京朝阳区100000

出　　处：《河北医学》2021年第4期539-542,共4页Hebei Medicine

基　　金：2018年度北京市自然科学基金,(编号:7182049)。

摘　　要：目的:探讨血清25(OH)维生素D3(VD3)水平和患者2型糖尿病周围神经病变(DPN)的相关性,并分析DPN的相关影响因素。方法:研究时间选取2018年1月至2019年1月,共收集航空总医院135例2型糖尿病住院患者,一组糖尿病不伴有2型周围神经病变(NDPN)组共有57例;另外一组则为DPN组患者78例。收集患者的性别比例,年龄,病程进行分析,采集并测定受试患者的HbA1c、FBG、PBG、Cr、ALT、LDL-C、VD3水平,统计NDPN组和DPN组VD3水平缺乏的比例,并对两组患者的VD3水平进行比较。采用Logistic回归分析DPN患者的独立危险因素,对DPN可能的病因进行初步探讨。结果:DPN组和NDPN组患者在病程值及糖化血红蛋白水平上存在着一定的差异(P<0.05)。DPN组患者平均血清VD3水平为(24.55±11.27)ng/mL,NDPN组水平为(50.43±18.48)ng/mL,DPN组患者VD3水平低于NDPN组VD3水平(P<0.05),93.6%的DPN组患者存在VD3缺乏,22.8%的NDPN患者存在VD3缺乏,DPN组VD3缺乏的比例更高(P<0.05)。经回归分析得知,病程和VD3是DPN的独立危险因素。结论:VD3水平缺乏在DPN患者中是比较普遍的,另外VD3缺乏与DPN的发生具有一定的相关,DPN的发生与进展可能和病程和VD3缺乏相关。Objective:To investigate the correlation between serum 25(OH)vitamin D3(VD3)levels and peripheral neuropathy(DPN)of patients with type 2 diabetes,and to analyze the related influencing factors of DPN.Methods:A total of 135 type 2 diabetes inpatients in the Aviation General Hospital from January 2018 to January 2019 were collected as research subjects.One group included 57 cases of diabetes without type 2 peripheral neuropathy(NDPN),and the other group included 78 patients of diabetes mellitus combined with type 2 peripheral neuropathy(DPN).The clinical data of all subjects for were collected for analysis,the HbA1c,FBG,PBG,Cr,ALT,LDL-C,and VD3 levels of the tested patients were measured,the proportion of the lack of VD3 levels in the NDPN group and the DPN group were counted,and VD3 level of patients in the two groups was compared.Logistic regression was used to analyze the independent risk factors of patients with DPN,and the possible causes of DPN were preliminarily discussed.Results:There was a certain difference in the course of disease and the level of glycosylated hemoglobin between the DPN group and the NDPN group(P<0.05).The average serum VD3 level in the DPN group was(24.55±11.27)ng/ml,and the level in the NDPN group was(50.43±18.48)ng/ml.The VD3 level in the DPN group was lower than that in the NDPN group(P<0.05).93.6%of the patients in the DPN group had VD3 deficiency,22.8%of NDPN patients had VD3 deficiency,and the proportion of VD3 deficiency in the DPN group was higher(P<0.05).Regression analysis showed that the course of disease and VD3 are independent risk factors for DPN.Conclusion:VD3 deficiency is relatively common in patients with DPN.In addition,VD3 deficiency is related to the occurrence of DPN.The occurrence and progression of DPN is related to VD3 deficiency.

关 键 词：血清25(OH)维生素D3 2型糖尿病 周围神经病变 

分 类 号：R58[医药卫生—内分泌]