慢性硬膜下血肿脂联素和基底膜蛋白多糖的表达  

Expression of adiponectin and perlecan in chronic subdural hematoma

作　　者：曹粒辉 刘晓 戴永建[3] 唐振刚[3] 刘岳 CAO Li-hui;LIU Xiao;DAI Yong-jian;TANG Zhen-gang;LIU Yue(Postgraduate Training Base of Hubei University of Medicine,Jinzhou Medical University,Shiyan 442000,China;Department of Neurosurgery,Xiangyang No.1 People's Hospital,Hubei University of Medicine,Xiangyang 441000,China;Department of Neurosurgery,Shiyan People's Hospital,Hubei University of Medicine,Shiyan 442000,China)

机构地区：[1]锦州医科大学湖北医药学院研究生培养基地,湖北十堰442000 [2]湖北医药学院附属襄阳市第一人民医院神经外科,湖北襄阳441000 [3]湖北医药学院附属十堰市人民医院神经外科,湖北十堰442000

出　　处：《中国临床神经外科杂志》2021年第4期278-280,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨慢性硬膜下血肿脂联素(APN)、基底膜蛋白多糖(PL)的表达变化。方法2019年5月至2020年5月钻孔引流术治疗CSDH共32例,所有病人入院后均服用阿托伐他汀钙片,直至复查CT示血肿完全吸收。术前、术后3 d、术后3周各取静脉血5 ml,术中采集血肿液5 ml,采用酶联免疫吸附法检测APN和PL的浓度。结果血肿液APN浓度([12.3±1.9)ng/ml]较外周血([13.8±0.7)ng/ml]明显降低(P<0.05),而PL浓度([10.9±4.3)ng/ml]较外周血([7.6±2.3)ng/ml]明显增高(P<0.05)。术后3 d外周血APN浓度([14.1±0.7)ng/ml]较术前无明显变化(P>0.05),术后3周外周血APN浓度([15.3±0.8)ng/ml]较术前明显增高(P<0.05)。血肿液APN浓度与血肿液PL浓度呈明显负相关(r=-0.585,P<0.01);血肿液APN浓度与血肿量呈明显负相关(r=-0.486,P<0.01);血肿液PL浓度与血肿量呈明显正相关(r=0.557,P<0.01)。结论本文结果提示APN和PL在CSDH发生、发展过程中具有一定作用,APN可作为CSDH阿托伐他汀治疗反应的评估指标。Objective To explore the expression of adiponectin(APN)and perlecan(PL)in the chronic subdural hematoma(CSDH).Methods The hemotoma and peripheral blood levels of APN and PL were detected in 32 patients with CSDH who underwent drilling drainage from May 2019 to May 2020 and received atorvastatin calcium tablets until the hemotomas were completely absorbed using the enzyme-linked immunosorbent assay.Results The APN concentration in hematoma[(12.3±1.9)ng/ml]was significantly lower that[(13.8±0.7)ng/ml]in peripheral blood before the operation(P<0.05),and PL concentration in hemotoma[(10.9±4.3)ng/ml]was significantly higher than that[(7.6±2.3)ng/ml]in peripheral blood before the operation(P<0.05).The APN concentration in peripheral blood 3 days after the surgery[(14.1±0.7)ng/ml;P>0.05]did not significantly changed and significantly increased 3 weeks after the surgery[(15.3±0.8)ng/ml;P<0.05]compared with before the surgery.The hematoma APN concentration was significantly negatively correlated with the hematoma PL concentration(r=0.585,P<0.01).The concentration of hematoma APN was significantly negatively correlated with the amount of hematoma(r=-0.486,P<0.01).The hematoma PL concentration was significantly positively correlated with the amount of hematoma(r=0.557,P<0.01).Conclusions Our results suggest that APN and PL have a certain role in the pathogenesis and development of CSDH,and the APN can be used as an assessment indicator of atorvastatin treatment for the CSDH.

关 键 词：慢性硬膜下血肿 脂联素 基底膜蛋白多糖 

分 类 号：R651.15[医药卫生—外科学] Q786[医药卫生—临床医学]