茵陈蒿汤防治肝脏疾病的药理作用及药动学研究进展  

Advances in pharmacology and pharmacokinetics of Yinchenhao Decotion in prevention and treatment of liver diseases

作　　者：王晶[1] 欧阳冰琛 WANG Jing;OUYANG Bingchen(Department of Pharmacy,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210001,China;Department of Clinical Pharmacology,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学附属南京中医院药学部,江苏南京210001 [2]南京中医药大学附属医院临床药理科,江苏南京210029

出　　处：《药物评价研究》2021年第3期628-637,共10页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(82004049);南京药学会—常州四药医院药学科研基金资助项目(2018YX001);江苏省药学会—奥赛康医院药学基金资助项目(A201808);南京市中医院科研基金项目(YJJC201901);南京市中医药青年人才培养计划(ZYQ20019)。

摘　　要：茵陈蒿汤源自《伤寒论》,为治疗湿热黄疸的经典方剂。药理研究发现其对多种类型肝损伤具有保护作用,可用于胆汁淤积、非酒精性脂肪肝、酒精性脂肪肝、肝纤维化、肝硬化的治疗,肝保护机制为调节胆红素胆汁酸代谢、降脂降糖、抗氧化、抑制肝星状细胞增殖和活化、抑制肝细胞凋亡、抗炎、调节肠道菌群。对茵陈蒿汤的药动学研究日渐增多,肝损伤对其药动学行为产生一定影响。综述茵陈蒿汤在肝脏疾病防治中的药理作用和药动学特征,为该方剂的开发应用和临床合理使用提供依据。Yinchenhao Decotion is originally described in shanghanlun, which is a classic prescription for the treatment of damp and hot jaundice. It has been confirmed for the therapeutic effects in various liver injuries, including cholestasis, nonalcoholic fatty liver,alcoholic fatty liver, liver fibrosis, cirrhosis. The hepatoprotective mechanism is related to the regulation of bile acid and bilirubin metabolism, lipid and glucose lowering, anti-oxidation, inhibition of activation and proliferation of hepatic stellate cells, inhibition of apoptosis of hepatic cells, anti-inflammatory and regulation of intestinal flora. Studies on the pharmacokinetics of Yinchenhao Decotion are increasing, and liver injury may influence its pharmacokinetic behavior. This review aims to summarize the pharmacological mechanism and pharmacokinetic characteristics of Yinchenhao Decotion in the prevention and treatment of liver diseases, so as to provide a basis for its further exploration and clinical application.

关 键 词：茵陈蒿汤 肝保护 药理作用 药动学 

分 类 号：R951[医药卫生—药学]