药食同源植物多糖治疗溃疡性结肠炎的药理作用及机制研究进展  

Research progress on pharmacological effects and mechanisms of plant polysaccharides with medicine and food homology in treatment of ulcerative colitis

作　　者：张琪琳[1,2] 舒亚民 潘祥林 张玉 王凯平[4] ZHANG Qilin;SHU Yamin;PAN Xianglin;ZHANG Yu;WANG Kaiping(Department of Pharmacy,Union Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,China;Hubei Province Clinical Research Center for Precision Medicine for Critical Illness,Wuhan 430022,China;Department of Pharmacy,Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China;College of Pharmacy,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属协和医院药学部,湖北武汉430022 [2]湖北省重大疾病精准用药临床医学研究中心,湖北武汉430022 [3]华中科技大学同济医学院附属同济医院药学部,湖北武汉430030 [4]华中科技大学同济医学院药学院,湖北武汉430030

出　　处：《药物评价研究》2021年第3期644-651,共8页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(81974509);湖北省自然科学基金资助项目(2017CFB273)。

摘　　要：溃疡性结肠炎(UC)是一种难治性慢性非特异性炎症肠道疾病,西医对UC发病机制并未完全阐明,目前尚无根治措施。近年来研究发现许多中药和药食同源的植物多糖治疗UC效果较好,且副作用小。本文主要对药食同源植物多糖黄芪多糖、当归多糖、马齿苋多糖、枸杞多糖、香菇多糖、猴头菌多糖等调节肠道微生态平衡、调节肠道免疫功能、抗炎、抗氧化、改善肠黏膜功能治疗UC的作用和机制进行综述,以期为UC的临床治疗和新药开发提供新思路和理论依据。Ulcerative colitis(UC) is a refractory chronic non-specific inflammatory bowel disease. Western medicine has not fully clarified the pathogenesis of UC, and there is no radical cure so far. In recent years, studies have found that many Chinese medicines and plant polysaccharides with medicine and food homology exhibited better effects in treating UC and have fewer side effects. In this article, the pharmacological effects and mechanisms of plant polysaccharides with medicine and food homology, such as astragalus polysaccharide, angelica polysaccharide, purslane polysaccharide, wolfberry polysaccharide, lentinan and hericium erinaceus polysaccharide in the treatment of UC via regulating the intestinal microecological balance, regulating the intestinal immune function, anti-inflammatory, anti-oxidation, and improving the intestinal mucosal function were reviewed. The main purpose of this article is to provide new ideas and theoretical basis for the clinical treatment and new drug development of UC.

关 键 词：植物多糖 溃疡性结肠炎 药理作用 作用机制 

分 类 号：R944.5[医药卫生—药剂学]