他汀类药物在急性肾损伤中的作用研究进展  

Advances in the role of statins in acute kidney disease

作　　者：胡权 廖晓辉[1] Hu Quan;Liao Xiao-hui(Department of Nephrology,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院肾内科,400010

出　　处：《临床肾脏病杂志》2021年第4期328-331,共4页Journal Of Clinical Nephrology

基　　金：国家自然基金面上项目(81873604);国家临床重点专科建设项目(卫生办医政[2012]649);重庆市科委科技局技术创新与应用发展面上项目(cstc2019jscx-msxm0157);重庆市留学人员创新创业计划(cx2018038)。

摘　　要：大量临床研究已经表明他汀类降脂药物可以延缓慢性肾脏病进展,减少心血管事件的发生率,在临床上广泛应用。急性肾损伤(acute kidney injury,AKI)目前尚无有效的药物治疗,近期有研究发现他汀类药物对AKI具有保护作用,提示他汀类药物有可能成为治疗AKI的药物。本文对他汀类药物在AKI的作用做一综述,以期为AKI的治疗提供新的思路。A growing number of clinical studies have shown that lipid-lowering statins can delay the progression of chronic kidney disease and reduce the incidence of cardiovascular events.Currently there is no effective drug treatment for acute kidney injury(AKI).Recent evidence has shown that statins have protective effects on AKI.This review focused upon the effects of statins on AKI so as to provide new rationales for the treatment of AKI.

关 键 词：他汀类药物 急性肾损伤 药物治疗 

分 类 号：R692[医药卫生—泌尿科学]