抗甲状腺球蛋白抗体(TG-Ab)和微粒体抗体(TM-Ab)与缺血性卒中患者颅内动脉血管狭窄的相关性研究  

Correlation of anti-thyroglobulin antibody(TG-Ab)and microsomal antibody(TM-AB)with intracranial artery stenosis in patients with ischemic stroke

作　　者：沈焱[1] 孙荣亮[2] 许瑞庭[3] 张启帆 SHENG Yan;SUN Rongliang;XU Ruiting;ZHANG Qifan(Department of Neurology,People′s Hospital of Ningxia Hui Autonomous Region Regian,Yinchuan 750002,China;Department of Cardiology,People′s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China;Department of Thoracic Surgery,People′s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China)

机构地区：[1]宁夏回族自治区人民医院神经内科,宁夏银川750002 [2]宁夏回族自治区人民医院心内科,宁夏银川750002 [3]宁夏回族自治区人民医院甲乳科,宁夏银川750002

出　　处：《宁夏医学杂志》2021年第4期302-304,共3页Ningxia Medical Journal

基　　金：宁夏卫生健康委科研课题(2019-NW-031)。

摘　　要：目的探讨抗甲状腺球蛋白抗体(TG-Ab)和甲状腺微粒体抗体(TM-Ab)与颅内动脉血管狭窄的关系,并评价其诊断价值。方法对233例缺血性脑血管病患者的资料进行回顾性分析,根据甲状腺抗体两项、经颅多普勒、颅脑磁共振血管造影、头颈部CT血管造影及数字减影血管造影的检测结果,将患者分为颅内动脉血管狭窄组120例和颅内血管非狭窄组113例。在入院时,对患者进行血清抗甲状腺球蛋白抗体、抗甲状腺微粒体抗体、肝肾功能、血同型半胱氨酸、血糖、血脂等指标进行检测。结果血清中抗甲状腺球蛋白抗体和抗甲状腺微粒体抗体水平相比,颅内血管狭窄组显著高于颅内血管非狭窄组(P<0.05)。结论甲状腺抗体两项水平与缺血性卒中患者颅内动脉血管狭窄呈正相关性,是缺血性脑血管病的一个危险因素,积极有效地降低其发生率可减少颅内动脉粥样硬化、降低缺血性脑血管病的发病率。Objective To investigate the relationship between anti-thyroglobulin antibody(TG-Ab)and thyroid microsomal antibody(TM-Ab)and intracranial arterial stenosis,and to evaluate their diagnostic value.Methods 233 patients with ischemic cerebrovascular disease were analyzed retrospectively,according to the thyroid antibody,TCD,MRA,CTA and DSA.The patients were divided into the intracranial arterial stenosis group(group A,n=120)and non-intracranial vascular stenosis group(group B,n=113).The serum anti-thyroglobulin antibody,anti-thyroid microsomal antibody,liver function,renal function,blood homocysteine,blood glucose,blood lipids and other indicators were tested.Result The serum levels of anti-thyroglobulin antibody and anti-thyroid microsomal antibody in intracranial vascular stenosis group were significantly higher than those in non-intracranial vascular stenosis group(P<0.05).Conclusion The level of thyroid antibody is positively correlated with intracranial artery stenosis in patients with ischemic stroke,which is a risk factor for ischemic cerebrovascular disease.Active and effective reduction of the elevated rate may reduce intracranial arteriosclerosis,reduce the incidence of ischemic cerebrovascular disease.

关 键 词：脑卒中 脑缺血 抗甲状腺球蛋白抗体 抗甲状腺微粒体抗体 颅内动脉血管狭窄 

分 类 号：R581[医药卫生—内分泌]