^(99m)Tc-TRODAT-1显像在帕金森病诊断中应用的研究进展  

Research progress of the application of ^(99m)Tc-TRODAT-1 imaging in the diagnosis of Parkinson's disease

作　　者：王玲[1] 文正伟[1] 唐坤[1] 李焕斌[1] WANG Ling;WEN Zhengwei;TANG Kun;LI Huanbin(Department of Nuclear Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China)

机构地区：[1]温州医科大学附属第一医院核医学科,浙江温州325000

出　　处：《老年医学研究》2021年第2期45-47,共3页Geriatrics Research

基　　金：浙江省温州市科技局公益性科技计划项目(Y20170833,SPECT^(99m)Tc-TRODAT-1脑显像对不同临床类型帕金森病患者的应用价值研究)。

摘　　要：帕金森病(PD)是最常见的神经退行性疾病之一,发病人数逐年上升。近年来,单光子发射计算机断层(SPECT)^(99m)Tc-TRODAT-1多巴胺转运蛋白(DAT)显像已被应用于PD的临床诊断。研究表明,^(99m)Tc-TRODAT-1有助于PD的早期诊断和鉴别诊断,并可对PD疾病的严重程度进行判断。另外,基于^(99m)Tc-TRODAT-1显像的影像组学和深度学习也对PD的诊断有一定价值。Parkinson's disease(PD)is one of the most common neurodegenerative diseases,and the number of cases is increasing year by year.In recent years,single photon emission computed tomography(SPECT)99mTc-TRODAT-1 dopa⁃mine transporter(DAT)imaging has been applied to the clinical diagnosis of PD.Studies have shown that ^(99m)Tc-TRODAT-1 may contribute to the early and differential diagnosis of PD and can be used to evaluate the severity of PD.In addition,the radiomics and deep learning method based on ^(99m)Tc-TRODAT-1 imaging also have certain diagnostic value for PD.

关 键 词：99mTc-TRODAT-1 帕金森病 多巴胺转运蛋白 显像 计算机断层摄影术 

分 类 号：R445.6[医药卫生—影像医学与核医学] R742.5[医药卫生—诊断学]