肝硬化继发急性上消化道出血的临床治疗研究  

Clinical Treatment of Acute Upper Gastrointestinal Hemorrhage Secondary to Cirrhosis

作　　者：朴成日[1] 宋伟[1] 车军[1] 金武丕[1] PIAO Chengri;SONG Wei;CHE Jun;JIN Wupi(Department of Emergency,Yanbian University Hospital,Yanji Jilin 133000,China)

机构地区：[1]延边大学附属医院急诊科,吉林延吉133000

出　　处：《中国卫生标准管理》2021年第7期95-97,共3页China Health Standard Management

摘　　要：目的研究肝硬化继发急性上消化道出血采用生长抑素并埃索美拉唑的临床治疗效果。方法医院2016年7月-2019年1月确诊并收治的156例肝硬化继发急性上消化道出血患者按照随机数字表法分为研究组和对照组。对照组采取常规对症治疗并生长抑素治疗,研究组在对照组基础上加用埃索美拉唑静脉滴注治疗。对比两组疗效、彻底止血时间、止血72 h后再出血率及住院时间,对比两组治疗前后的超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及皮质醇(COR)水平。结果研究组总有效率显著高于对照组(P<0.05)。研究组止血时间、再出血率及住院时间显著优于对照组(P<0.05)。研究组治疗后COR、hs-CRP及TNF-α显著好于同期对照组(P<0.05)。两组均无显著不良反应发生。结论肝硬化继发急性上消化道出血采用生长抑素并埃索美拉唑疗效确切,可显著促进止血并巩固止血效果,促进患者恢复,安全性好。Objective To study the clinical effect of somatostatin and Esomeprazole in the treatment of acute upper gastrointestinal hemorrhage secondary to cirrhosis.Methods From July 2016 to January 2019,156 patients with acute upper gastrointestinal hemorrhage secondary to cirrhosis were divided into study group and control group according to the random number table method.The control group was treated with routine symptomatic therapy and somatostatin,and the study group was treated with esomeprazole intravenous drip on the basis of the control group.The therapeutic effect,the time of complete hemostasis,the rate of rebleeding and the time of hospitalization after 72 h of hemostasis were compared between the two groups.The levels of hs-CRP,TNF-αand COR before and after treatment were compared between the two groups.Results The total effective rate of the study group significantly higher than control group(P<0.05).The hemostasis time,rebleeding rate and hospitalization time in the study group were significantly better than those in the control group(P<0.05).After treatment,the cor,hs CRP and TNF-αin the study group were significantly better than those in the control group(P<0.05).Conclusion somatostatin combined with esomeprazole is effective in the treatment of acute upper gastrointestinal hemorrhage secondary to cirrhosis,which can significantly promote the hemostasis and consolidate the hemostasis effect,promote the recovery of patients,and have good safety.

关 键 词：肝硬化 门静脉高压 急性 上消化道出血 生长抑素 埃索美拉唑 

分 类 号：R657[医药卫生—外科学]