1,2-二(2-甲氧基苯基)-1,2-乙二胺的制备方法研究  

Study on Synthesis Method of 1,2-Bis(2-methoxyphenyl)-1,2-ethanediamine

作　　者：邸相杰 邹胜[1] 黄晴菲[1] 范挺[1] 王启卫[1] DI Xiang-jie;ZOU Sheng;HUANG Qing-fei;FAN Ting;WANG Qi-wei(Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;University of Chinese Academy of Sciences, Beijing 100049, China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]中国科学院大学,北京100491

出　　处：《合成化学》2021年第4期315-319,共5页Chinese Journal of Synthetic Chemistry

基　　金：中国科学院“西部之光”人才培养计划。

摘　　要：手性1,2-二(2-甲氧基苯基)-1,2-乙二胺可作为有机小分子催化剂、金属配体前体广泛应用于多种有机合成反应之中,其可以消旋体为原料通过拆分得到。以廉价易得的邻甲氧基苯甲醛为原料,重点针对亚胺中间体还原过程中反应条件苛刻、后处理复杂等问题,首次利用Mg作为还原剂,在室温下,以93%的分离收率得到关键中间体3。通过该关键步骤的放大实验(92%),进一步评价了该方法的应用潜力。As a key organic small molecule catalyst and ligand precursors in metal catalysis,chiral 1,2-bis(2-methoxyphenyl)-1,2-ethylenediamine can be applied in various organic synthesis reactions,which can be obtained through racemic resolution.Typically,reduction of imine intermediate exhibited the problem of harsh reaction conditions.Here,cheap o-methoxybenzaldehyde was used as raw material and Mg was used as reducing agent.The key intermediate 3 could be obtained with 93%isolated yield under ambient temperature.Meanwhile,through the large-scale experiment of the key step(92%),the industrial application potential of the method is further evaluated.

关 键 词：邻甲氧基苯甲醛 亚胺 乙二胺 还原 手性拆分 合成 放大实验 

分 类 号：O62[理学—有机化学]