青岛市部分患者与献血者人群Rh表型及单体型频率分布特征分析  

The distribution characteristics of Rh phenotype and haplotype frequency in Qingdao:An analysis based on some patients and local blood donors

作　　者：孙波[1] 孙小媛 邵长峰[1] 刘艳[1] 刘政 杨元铭[1] 黄祖洲 张长凯 王海燕[1] SUN Bo;SUN Xiaoyuan;SHAO Changfeng;LIU Yan;LIU Zheng;YANG Yuanming;HUANG Zuzhou;ZHANG Changkai;WANG Haiyan(Department of Blood Transfusion,the Affiliated Hospital of Qingdao Uni-versity,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院输血科,山东青岛266000

出　　处：《中国输血杂志》2021年第3期205-207,共3页Chinese Journal of Blood Transfusion

摘　　要：目的了解本院患者人群与本地献血者人群Rh血型系统抗原表型及单体型和不规则抗体等的分布特征,以确保临床安全、有效输血及提高临床用血合理性与科学性。方法选取本院2015年10月~2020年3月住院患者和在此期间青岛市中心血站发往本院的献血者血液共113 326人(份)的Rh抗原分型和不规则抗体检测结果数据,回顾性分析并计算其Rh表型、单体型及不规则抗体的分布频率。不同人群间的比较采用χ2检验。Rh抗原分型和不规则抗体检测均在全自动血型分析仪上完成。结果本组受试人群的RhD阴性率为0.36%(408/113 326);常见的Rh表型为DCCee[40.69%(46 112/113 326)]、DCcEe[36.82%(41 727/113 326)];不规则抗体最多的是抗-E[0.26%(295/113 326)];最常见的单体型是DCe[62.51%(70 840/113 326)]。而在德国白人、北印度人和北非人中最常见的Rh表型分别为DCcee、DCCee、Dccee,最常见的单体型分别为DCe、DCe、Dce。结论本院就诊患者及本市献血者Rh表型、单体型和不规则抗体的分布特征符合中国北方地区人群的分布规律;可据此制定备(贮)血及采(献)供血计划,有针对性的建立Rh血型资料库,切实保障临床用血安全、合理、科学,提升精准输血医学水平。Objective To investigate the distribution characteristics of Rh blood group antigen phenotypes, haplotypes and irregular antibodies between patients in our hospital and local blood donors, so as to ensure safe and effective blood transfusion and improve the rationality and scientificity of clinical blood transfusion. Methods A total of 113 326 blood samples, from hospitalized patients in our hospital and local blood donors from October 2015 to March 2020, were subjected to Rh antigen typing and irregular antibody detection. The frequency of Rh phenotypes, haplotypes, and irregular antibodies were retrospectively analyzed and calculated. Chi square test was used to compare the data among different population groups. Rh antigen typing and irregular antibody detection were completed using the automatic blood group analyzer. Results The prevalence of negative RhD was 0.36%(408/113 326).The most prevalent Rh phenotype was DCCee [40.69%(46 112/113 326)] followed by DCcEe[36.82%(41 727/113 326)]. Anti-E was the most common irregular antibody, accounting for [0.26%(295/113 326)], and DCe[62.51%(70 840/113 326)] was the most common haplotype. The most common Rh phenotypes and haplotypes in Caucasians in Germany, North Indian and North African were DCcee, DCCee and Dccee, while DCe, DCe and Dce, respectively. Conclusion The distribution characteristics of Rh phenotypes, haplotypes and irregular antibodies of patients in our hospital and local blood donors were in line with the distribution characteristics of the population in northern China. Corresponding plans concerning blood storage and collection, as well as the establishment of Rh blood type registry should be carried to effectively ensure the safety, rationality and accuracy of clinical blood transfusion.

关 键 词：Rh血型表型 Rh单体型 不规则抗体 就诊患者 献血者 中国北方人群 输血 

分 类 号：R457.11[医药卫生—治疗学]