L-a17在体外血浆和人工胃肠液中的稳定性研究  

Study on Stability of L-a17 in Plasma in Vitro and Simulated Gastric/Intestinal Fluid

作　　者：李爱红 张宇 廖伟科 LI Ai-hong;ZHANG Yu;LIAO Wei-ke(School of Pharmacy,Guizhou Medical University,Guizhou Guiyang 550004;Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D,Guizhou Guiyang 550004,China)

机构地区：[1]贵州医科大学药学院,贵州贵阳550004 [2]贵州省化学合成药物研发利用工程技术研究中心,贵州贵阳550004

出　　处：《广州化工》2021年第8期60-63,共4页GuangZhou Chemical Industry

基　　金：贵州省科技支撑计划(黔科合支撑[2019]2761号)。

摘　　要：考察L-a17在体外血浆和人工胃/肠液中的稳定性,有助于针对性的进行药物结构优化,提高药物的吸收率,更有效的指导药物制剂的开发。采用高效液相色谱法,检测L-a17在大鼠血浆和空白人工胃/肠液、人工胃/肠液中孵育不同时间的含量变化,计算剩余百分含量。结果表明L-a17在大鼠血浆及空白人工胃/肠液、人工胃/肠液中孵育不同时间的剩余百分比均在(84.01±0.51)%~(105.57±0.84)%范围内。L-a17在大鼠体外血浆及模拟人工胃/肠液中稳定性良好。Observing the stability of L-a17 in plasma in vitro and simulated gastric/intestinal fluidswill help to optimize the structure of drugs,improve the absorption rate of drugs,and guide the development of pharmaceutical preparations more effectively.The content changes of L-a17 in rat plasma,blank simulated gastric/intestinal fluids and simulated gastric/intestinal fluids at different incubation time were detected by HPLC,and the remaining percentage content was calculated.The results showed that the remaining percentages of L-a17 in rat plasma and blank simulated gastric/intestinal fluid,and simulated gastric/intestinal fluid for different time were in the range of(84.01±0.51)%to(105.57±0.84)%.L-a17 was stable in plasma in vitro and simulated gastric/intestinal fluids.

关 键 词：L-a17 体外血浆 人工胃液 人工肠液 稳定性 

分 类 号：R96[医药卫生—药理学]