Apolipoprotein E variants correlate with the clinical presentation of paediatric inflammatory bowel disease:A cross-sectional study  

作　　者：Aleksandra Glapa-Nowak Mariusz Szczepanik Barbara Iwańczak Jarosław Kwiecień Anna Barbara Szaflarska-Popławska Urszula Grzybowska-Chlebowczyk Marcin Osiecki Marcin Dziekiewicz Andrzej Stawarski Jarosław Kierkuś Tomasz Banasiewicz Aleksandra Banaszkiewicz Jarosław Walkowiak 

机构地区：[1]Department of Pediatric Gastroenterology and Metabolic Diseases,PoznańUniversity of Medical Sciences,Poznań60-572,Poland [2]Department of Pediatrics,Medical University of Wroclaw,Wroclaw 50-369,Poland [3]Department of Pediatrics,Faculty of Medical Sciences in Zabrze,Medical University of Silesia,Zabrze 41-800,Poland [4]Department of Pediatrics,Faculty of Medical Sciences,Medical University of Silesia in Katowice,Katowice 40-752,Poland [5]Department of Gastroenterology,Hepatology,Feeding Disorders and Paediatrics,The Children’s Memorial Health Institute,Warsaw 04-730,Poland [6]Department of Pediatric Gastroenterology and Nutrition,Medical University of Warsaw,Warsaw 02-091,Poland [7]Department and Clinic of Pediatrics,Gastroenterology and Nutrition,Wroclaw Medical University,Wroclaw 50-369,Poland [8]Chair and Department of General Surgery,Gastroenterological Surgical Oncology and Plastic Surgery,PoznańUniversity of Medical Sciences,Poznań60-355,Poland

出　　处：《World Journal of Gastroenterology》2021年第14期1483-1496,共14页世界胃肠病学杂志（英文版）

基　　金：The National Science Centre,Poland,No.2017/25/B/NZ5/02783(to Walkowiak J).

摘　　要：BACKGROUND It has been suggested that apolipoprotein E(APOE)polymorphisms are associated with the risk of developing inflammatory bowel disease(IBD)and the early age of disease onset.However,there are no reports regarding the relationship with clinical characteristics and disease severity.AIM To summarise that APOE polymorphisms are associated with the risk of developing IBD and the early age of disease onset.METHODS In total,406 patients aged 3-18 with IBD(192 had ulcerative colitis and 214 had Crohn’s disease)were genotyped using the TaqMan hydrolysis probe assay.Clinical expression was described at diagnosis and the worst flare by disease activity scales,albumin and C-reactive protein levels,localisation and behaviour(Paris classification).Systemic steroid intake with the total number of courses,immunosuppressive,biological,and surgical treatment with the time and age of the first intervention were determined.The total number of exacerbation-caused hospitalisations,the number of days spent in hospital due to exacerbation,the number of relapses,and severe relapses were also estimated.RESULTS Ulcerative colitis patients with the APOEε4 allele had lower C-reactive protein values at diagnosis(P=0.0435)and the worst flare(P=0.0013)compared to patients with the APOEε2 allele and genotype APOEε3/ε3.Crohn’s disease patients with the APOEε2 allele scored lower on the Pediatric Crohn’s Disease Activity Index at diagnosis(P=0.0204).IBD patients with APOEε2 allele spent fewer days in the hospital due to relapse(P=0.0440).CONCLUSION APOE polymorphisms are associated with the risk of developing IBD and the clinical expression of IBD.However,the clinical relevance of the differences identified is rather modest.

关 键 词：Apolipoprotein E polymorphism Crohn’s disease Ulcerative colitis IMMUNOSUPPRESSION SURGERY Disease severity 

分 类 号：R725.7[医药卫生—儿科]