动脉硬化患者胱硫醚β-合成酶基因多态性及其与临床的关联性  

Mutation of cystathionine gene in patients with carotid plaque and its correlation with clinic

作　　者：蓝家富[1] 梁烨[2] 李近都 曾德创[4] 李天资[4] 潘兴寿[4] Lan Jiafu;Liang Ye;Li Jindu;Zeng Dechuang;Li Tianzi;Pan Xingshou(Department of Ultrasound,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China;Department of Teaching,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China;Cancer Hospital Affiliated to Guangxi Medical University,Nanning 530021,China;Department of Cardiovascular Medicine,Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院附属医院超声科,百色533000 [2]右江民族医学院附属医院教学部,百色533000 [3]广西医科大学附属肿瘤医院肝胆外科,南宁530021 [4]右江民族医学院附属医院心血管内科,百色533000

出　　处：《中华临床营养杂志》2020年第5期283-289,共7页Chinese Journal of Clinical Nutrition

基　　金：国家自然科学基金(81060028);广西重大专项基金(桂科重1598005-9);广西自然科学基金(2019JJA140159);百色市科技术专项基金(百科计20130106,20140923,20180038)。

摘　　要：目的探讨动脉粥样硬化患者胱硫醚酶基因多态性及其与临床的关联性。方法在颈动脉超声检查的高血压患者中,随机抽取114例颈动脉中内膜增厚或斑块阳性的患者作为研究组,检测其身高、体重、血压、血脂、血糖、血尿酸、同型半胱氨酸(homocysteine,HCY)水平,并检测CBS基因G919A和T883C位点碱基,并与155例颈动脉正常的高血压患者作为对照组比较。结果研究组体重指数、收缩压、总胆固醇、甘油三酯、空腹血糖、血尿酸、HCY水平高于对照组,差异有统计学意义(P<0.05)。研究组舒张压和高密度脂蛋白胆固醇水平与对照组比较差异无统计学意义(P>0.05)。血尿酸,收缩压和CBS基因T883C位点突变是颈动脉粥样硬化的独立危险因素(P<0.05)。其风险关系分别为1.4倍、2.0倍和3.3倍;性别、年龄、体重指数、舒张压、总胆固醇、甘油三酯、血尿酸、HCY和CBS基因G919A位点等观察指标与颈动脉粥样硬化不存在风险关系(P>0.05)。颈动脉粥样硬化的高血压患者CBS基因T883C位点次等位基因突变率高。结论颈动脉粥样硬化的高血压患者血压、血脂、血糖、血尿酸、HCY水平高、收缩压、血尿酸和CBS基因T883C位点多态性是颈动脉粥样硬化的独立危险因素,其CBS基因T883C次等位基因突变率高。Objective To investigate the Cystathionine-β-synthase(CBS)gene polymorphism in patients with atherosclerosis and its clinical relevance.Methods 114 hypertensive patients with carotid plaque based on ultrasonography were randomly selected as study group with 155 hypertensive patients without carotid plaque as control group.Height,weight,blood pressure,levels of blood lipid,blood glucose,blood uric acid and homocysteine(HCY),and polymorphism of CBS gene G919A and T883C loci were detected and compared between groups.Results Patients in study group had significantly higher body mass index,systolic blood pressure,total cholesterol,triglyceride,fasting blood glucose,blood uric acid,and HCY levels than those in control group(P<0.01 or P<0.05)while the levels of diastolic blood pressure and high density lipoprotein cholesterol showed no significant difference between groups(P>0.05).Systolic blood pressure,uric acid and CBS T883C mutation are independent risk factors of carotid plaque(P<0.05)with the odds ratio of 2.0,1.4 and 3.3,respectively.Gender,age,BMI,diastolic blood pressure,total cholesterol,triglyceride,serum uric acid and HCY were not associated with carotid plaque(P>0.05).The frequency of both CBS G919A and T883C mutations were higher in hypertensive patients with carotid plaque,but only the difference in T883C mutation reached significance.Conclusions Hypertensive patients with carotid atherosclerosis have higher levels of blood pressure,blood lipid,blood glucose,uric acid and HCY and show higher frequency of CBS T883C mutation.Systolic pressure,uric acid and CBS T883C mutation are independent risk factors of carotid atherosclerosis.

关 键 词：高血压 动脉粥样硬化 胱硫醚酶基因 危险因素 

分 类 号：R543.4[医药卫生—心血管疾病]