噻吗洛尔外敷联合^(32)P敷贴治疗婴幼儿血管瘤的疗效观察  

Efficacy of timolol plus ^(32)P applicator brachytherapy for infantile hemangioma

作　　者：李宗良[1] 马荣欣 魏雁[1] 冯艳丽[3] 左江华[3] Li Zongliang;Ma Rongxin;Wei Yan;Feng Yanli;Zuo Jianghua(Department of Nuclear Medicine,Municipal People's Hospital,Xingtai 054001,China;Department of Pharmacy,Municipal People's Hospital,Xingtai 054001,China;Department of Clinical Laboratory,Municipal People's Hospital,Xingtai 054001,China)

机构地区：[1]河北省邢台市人民医院核医学科,河北省邢台市054001 [2]河北省邢台市人民医院药剂科,河北省邢台市054001 [3]河北省邢台市人民医院检验科,河北省邢台市054001

出　　处：《临床小儿外科杂志》2021年第4期354-358,共5页Journal of Clinical Pediatric Surgery

基　　金：河北省青年科技课题计划项目(编号:20201580)。

摘　　要：目的观察噻吗洛尔外敷联合^(32)P敷贴治疗婴幼儿血管瘤的临床疗效。方法选取河北省邢台市人民医院120例婴幼儿血管瘤患者作为研究对象,按照随机数字表法分成观察组和对照组,每组60例。观察组第一疗程采用^(32)P敷贴治疗,之后改为单独噻吗洛尔外敷治疗;对照组全程采用^(32)P敷贴治疗,最多给予3个疗程的治疗。对两组临床总有效率和副作用发生情况进行比较分析。结果两组患者的年龄、性别、血管瘤面积和部位差异无统计学意义(P>0.05),具有可比性。观察组治愈26例,总有效率为93.33%(56/60);对照组治愈29例,总有效率为96.67%(58/60),两组总有效率比较差异无统计学意义(χ^(2)=0.702,P>0.05)。治疗后第4个月,观察组的治愈率为26.67%,低于对照组的45.00%,差异有统计学意义(χ^(2)=4.385,P=0.036);治疗后第6个月,两组治愈率无差异(χ^(2)=0.302,P=0.583)。观察组的副作用发生率低于对照组(16.67%vs.45.00%),差异有统计学意义(P<0.01)。结论噻吗洛尔外敷联合^(32)P敷贴治疗婴幼儿血管瘤疗效确定、临床效果满意,能有效降低色素脱失和色素沉着等副作用的发生率。Objective To explore the clinical efficacy of timolol plus ^(32)P applicator brachytherapy for infantile hemangioma(IH).Methods A total of 120 IH children were selected as subjects.They were randomly divided into observation and control groups(n=60 each).The observation group received an initial course of ^(32)P applicator and a subsequent therapy of timolol alone.The control group received a whole course of ^(32)P applicator for at most 3 sessions.The total effective rate and side effects of two groups were compared.Results No significant inter-group difference existed in age,gender,hemangioma area or site(P>0.05).In observation group,26 cases were cured with a total effective rate of 93.33%(56/60)while 29 cases were cured with a total effective rate of 96.67%(58/60)in control group.No inter-group difference of statistical significance existed in total effective rate(χ^(2)=0.702,P>0.05).The incidence of side effects was significantly lower in observation group than that in control group(P<0.01).At Month 4 of treatment,the cure rate of observation group was lower than that of control group(χ^(2)=4.385,P=0.036)while no inter-group difference in cure rate at Month 6(χ^(2)=0.302,P=0.583).The incidence of side effects was significantly lower in observation group than that in control group.And the difference was statistically significant(P<0.01).Conclusion With a definite and satisfactory efficacy for IH,a combination of timolol and ^(32)P application may effectively reduce the incidence of such side effects as depigmentation and pigmentation.

关 键 词：血管瘤/治疗 噻吗洛尔 ^(32)P敷贴 治疗结果 婴幼儿 

分 类 号：R543[医药卫生—心血管疾病] R732.2[医药卫生—内科学]