姜黄素的生物活性及其调节动物肠道黏膜屏障功能的分子机制  

Biological Activity of Curcumin and Its Molecular Mechanism Regulating Intestinal Mucosal Barrier Function of Animals

作　　者：阮栋 王一冰 蒋守群 郑春田 RUAN Dong;WANG Yibing;JIANG Shouqun;ZHENG Chuntian(Guangdong Key Laboratory of Animal Breeding and Nutrition,Key Laboratory of Animal Nutrition and Feed Science of ministry of Agriculture in South China,State Key Laboratory of Livestock and Poultry Breeding,Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China)

机构地区：[1]广东省农业科学院动物科学研究所,畜禽育种国家重点实验室,农业部华南动物营养与饲料重点实验室,广东省畜禽育种与营养重点实验室,广州510640

出　　处：《动物营养学报》2021年第4期1801-1810,共10页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：广东省自然科学基金项目(2019A1515010912);国家现代农业产业技术体系(CARS⁃42⁃13,CARS⁃41⁃G10);国家重点研发项目(2018YFD0501504,2018YFD0500600);动物健康养殖国际科技合作示范基地(2019A050505007);广东省科技计划项目(2017B020202003);广州市科技计划重点项目(201804020091,201904020001);广东省农业科学院高水平科技创新战略建设专项资金(R2017YJ⁃YB3005,R2018QD⁃073)。

摘　　要：姜黄素是从姜科植物姜黄中提取的一种天然植物多酚类物质,具有抗氧化、抗细胞凋亡、抗炎、免疫调节和代谢调控等功能。研究表明,姜黄素主要通过模式识别受体、核受体、细胞凋亡和细胞自噬等信号通路发挥其生理作用,还能够通过细胞能量代谢调控细胞增殖与分化。本文主要综述姜黄素调节动物肠道黏膜屏障功能的作用机制,为新型饲料添加剂的开发及其在畜禽养殖中应用提供科学理论依据。Curcumin is a natural plant polyphenol derived from the rhizomes of Curcuma longa that has antioxi⁃dant,anti⁃apoptosis,anti⁃inflammatory,immune modulation and metabolic regulation properties.Research shows that curcumin exerts physiological function mainly through pattern recognition receptors,nuclear recep⁃tors,apoptosis and autophagy signal pathways,and modulates cell proliferation and differentiation through en⁃ergy metabolism.This review mainly expounded the mechanism of curcumin maintaining intestinal mucosal barrier function,in order to provide scientific theoretical basis for the development of new feed additives and animal breeding.

关 键 词：姜黄素 吸收与代谢 肠道黏膜屏障 分子机制 

分 类 号：S811[农业科学—畜牧学] S816.7[农业科学—畜牧兽医]