650 nm半导体激光控制青少年近视进展的研究  

Effect of 650 nm semiconductor laser on juvenile myopia control

作　　者：闫艺 薛文娟 赵延军 祝剑锋[2] 王平[1] 房祥杰 刘建峰 刘丽[2] 付海涛[2] 焦国帅 Yan Yi;Xue Wenjuan;Zhao Yanjun;Zhu Jianfeng;Wang Ping;Fang Xiangjie;Liu Jianfeng;Liu Li;Fu Haitao;Jiao Guoshuai(Department of Qingdao University,Qingdao 266000,China;Department of Linyi People’s Hospital of Qingdao University,Linyi 276000,China;Department of Anyang Tongguang Ophthalmic Center,Anyang 455000,China)

机构地区：[1]青岛大学,266000 [2]山东省临沂市人民医院眼科 [3]安阳市童光眼科中心

出　　处：《临床眼科杂志》2021年第2期132-137,共6页Journal of Clinical Ophthalmology

基　　金：山东省医药卫生科技发展计划(2017WSA13049)。

摘　　要：目的观察650 nm红光对青少年近视进展的影响。方法随机对照研究。在临沂市人民医院就诊的患者中,连续入选7~12岁近视患者120例(120只眼),双眼纳入研究过程,统一选取右眼数据进行分析,分为红光组60例(60只眼)和对照组60例(60只眼)。红光组采用单波长650 nm红光进行防控干预,非干预时间佩戴单焦点框架眼镜,对照组佩戴单焦点框架眼镜进行日常活动。观察并比较干预前和干预后的1、3、6、12个月患者的等效球镜度(SE)、眼轴长度(AL)后极部黄斑中心凹下的脉络膜厚度(SFCT)及裸眼视力(UCVA)。采用重复测量方差分析、独立样本t检验对数据进行统计学分析。结果与干预前相比,干预1、3、6、12个月后,红光组SE基本保持稳定,对照组逐渐增大,两组比较差异均有统计学意义(均P<0.05);干预1、3、6、12个月后,红光组AL缩短并逐渐趋于稳定,对照组AL延长,两组比较均差异有统计学意义(均P<0.05);干预1、3、6、12个月后,红光组SFCT逐渐趋于稳定,对照组SFCT变薄,两组比较差异均有统计学意义(均P<0.05);干预1、3、6、12个月后,红光组UCVA基本保持稳定,对照组UCVA逐渐下降,两组比较差异均有统计学意义(均P<0.05)。干预后红光组未出现畏光、流泪、结膜充血、水肿、角膜上皮损伤、晶状体混浊、黄斑损害等眼部并发症,亦未发现认知障碍及行为异常。结论650 nm红光可有效延缓青少年近视进展,未见明显不良反应。Objective To investigate the effect of 650 nm red light on the juvenile myopia progression.Methods A total of 120 schoolchildren(120 eyes)aged 7-12 years with myopia at our hospital were selected for a randomized controlled study,and their right eyes were selected for the analysis.The participants were divided into the red light group(60 eyes)and control group(60 eyes).Participants in the red light group were treated with single wavelength 650nm red light for myopia control,while the control group particpants did not receive any intervention.The spherical equivalent(SE),axial length(AL),subfoveal macular choroidal thicknessand uncorrected visual acuity were observed and compared before and at 1,3,6 and 12 months after the intervention.The data were analyzed by repeated measures analysis of variance and by independent t-tests.Results After 1,3,6 and 12 months of intervention,the SE in the red light group remained basically stable,while SE in the control group gradually increased.The between-group difference was statistically significant(P<0.05).After 1,3,6 and 12 months of intervention,the AL in the red light group was reduced and gradually stabilized,while that in the control group was increased.The between-group difference was statistically significant(P<0.05).After 1,3,6 and 12 months of intervention,the subfoveal macular choroidal thickness in the red light group increased and tended to be stable,while that in the control group reduced.The between-group difference was statistically significant(P<0.05).After 1,3,6 and 12 months of intervention,the uncorrected visual acuity in the red light group remained basically stable,while that in the control group gradually decreased.The between-group difference was also statistically significant(P<0.05).No ocular complications was observed in the red light group after the intervention,including conjunctival congestion,corneal edema,photophobia,lacrimation,corneal ulcer,cataract,macular damage and cognitive impairment and behavioral abnormalities.Conclusions The 650nm red

关 键 词：650 nm红光 等效球镜 眼轴 黄斑下脉络膜厚度 裸眼视力 

分 类 号：R47[医药卫生—护理学]