PEDV编码蛋白拮抗宿主天然免疫的研究进展  

Research Progress on the Antagonistic Effect of PEDV Encoded Protein on Host Innate Immunity

作　　者：宋海鑫 丁芳艺 梁荣 苗晋锋[2] 卢宇[1,2,3,4,5] 刘永杰 张金秋[1,3,4,5] SONG Haixin;DING Fangyi;LIANG Rong;MIAO Jinfeng;LU Yu;LIU Yongjie;ZHANG Jinqiu(Institute of Wterinary Immunology and Engineering,Jiangsu Academy of Agricultural Sciences,Nanjing 210014,China;College of veterinary medicine,Nanjing AgiicultiiraI University,Nanjing 210095,China;Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base,Nanjing 210014,China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou 225009,China;College of Pharmacy,Jiangsu University,Zhenjiang 212013,China)

机构地区：[1]江苏省农业科学院动物免疫工程研究所,南京210014 [2]南京农业大学动物医学院,南京210095 [3]省部共建国家重点实验室培育基地-江苏省食品质量安全重点实验室,南京210014 [4]江苏省动物重要疫病与人兽共患病防控协同创新中心,扬州225009 [5]江苏大学药学院,镇江212013

出　　处：《中国动物传染病学报》2021年第2期107-113,共7页Chinese Journal of Animal Infectious Diseases

基　　金：国家自然科学基金(31772701);江苏省农业科技自主创新资金(CX(17)3027)。

摘　　要：猪流行性腹泻病毒(PEDV)属于冠状病毒家族成员,是近年来引起新生仔猪水样腹泻致死的主要病原之一,给养殖业带来了巨大威胁。病毒感染后,宿主细胞通过模式识别受体(PRRs)识别病原相关分子模式(PAMPs),促进I型干扰素等细胞因子的产生,进而抑制病毒的增殖。近年来的研究表明,PEDV能够通过其编码蛋白对宿主的抗病毒天然免疫反应进行调节,成功逃避免疫识别或拮抗宿主的天然免疫反应,为自身的快速复制和增殖创造条件。本文结合目前关于PEDV与宿主细胞相互作用的研究进展,综合分析了PEDV编码的各种蛋白在感染过程中拮抗宿主天然免疫系统的分子机制,旨在为进一步认识PEDV乃至其他冠状病毒的致病机制,也为探索新的抗病毒药物靶标提供思路。Porcine epidemic diarrhea virus (PEDV) is a member of the coronavirus family and a main cause of deaths from watery diarrhea in newborn pigs in recent years,posing a great threat to swine industry.After the infection of PEDV,host cells recognize the pathogen-related molecular pattern (PAMPs) by pattern recognition receptor (PRRs) and produce cytokines like typeⅠinterferon that consequently inhibit the proliferation of the viruses.However,recent studies have shown that PEDV regulates the innate immune response of host cells by its encoded protein and then successfully evades the identification of innate immune system or antagonizes the anti-virus response for its rapid replication and proliferation.Based on the current research progresses on the interaction between PEDV and host cells,this paper analyzes the molecular mechanisms of various proteins encoded by PEDV in the process of infection,aiming to further understand the pathogenic mechanism of PEDV and other coronaviruses and explore new antiviral drug targets.

关 键 词：猪流行性腹泻病毒 天然免疫 干扰素 拮抗剂 

分 类 号：S852.659.6[农业科学—基础兽医学]