胰岛类器官研究进展  

Advances in research of islet organoids

作　　者：吴倩[1,2] 张梅 Wu Qian;Zhang Mei(Department of Endocrinology,the First Affiliated Hospital with Nanjing Medical University,Nanjing 210029,China;Department of Endocrinology,Taikang Xianlin Drum Tower Hospital,Nanjing University School of Medicine,Nanjing 210046,China)

机构地区：[1]南京医科大学第一附属医院(江苏省人民医院)内分泌科,210029 [2]南京市泰康仙林鼓楼医院内分泌科,210046

出　　处：《中华细胞与干细胞杂志（电子版）》2021年第2期120-124,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金(81370939,81670756,81974103);江苏省重点研发项目(BE2018748);江苏省“333高层次人才培养工程”(LGY2016007)。

摘　　要：类器官是将具有多向分化潜能的干细胞或组织细胞在特定环境下培养分化成为能够模拟原生器官结构和功能的三维结构。类器官在各种疾病模型研究及药物筛选中发挥至关重要的作用。近年来,通过体外诱导胰腺组织或多能干细胞分化形成具有胰岛细胞功能的胰岛类器官研究成为热点,为胰岛相关疾病模型、药物研究以及糖尿病的治疗提供了新的手段。本文针对胰岛类器官的体外诱导方法及应用前景作一综述。Organoids are defined as three-dimensional cellular aggregations differentiated from pluripotent stem cells or adult tissues by cultivating in specific environment,which recapitulate the intricate pattern and function of the original tissue.Organoids play an important role in disease modeling and drug screening.In recent years,differentiating pancreatic tissue or stem cells into pancreatic islet organoids have become a hotspot and provided new ideas for the treatment of diabetes.In this paper,the vitro induction methods and the application prospect of islet organoids are reviewed.

关 键 词：类器官 胰岛细胞 人多能干细胞 

分 类 号：R587.1[医药卫生—内分泌]