树突状表皮T细胞在胸腺内发育的研究进展  

Development of dendritic epidermal T cells in thymus

作　　者：李雅舒 张小容 胡晓红 黄勇 罗高兴 贺伟峰 Li Yashu;Zhang Xiaorong;Hu Xiaohong;Huang Yong;Luo Gaoxing;He Weifeng(Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200011,China;Institute of Bum Research,State Key Laboratory of Trauma,Bum and Combined Injury,Key Laboratory of Disease Proteomics of Chongqing,Southwest Hospital,Third Military Medical University(Army Medical Un Oiversity),Chongqing 400038,China)

机构地区：[1]上海交通大学医学院附属第九人民医院整复外科,200011 [2]陆军军医大学(第三军医大学)第一附属医院全军烧伤研究所,创伤、烧伤与复合伤国家重点实验室,重庆市疾病蛋白质组学重点实验室,重庆400038

出　　处：《中华细胞与干细胞杂志（电子版）》2021年第2期125-128,共4页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金青年科学基金(32000645)。

摘　　要：树突状表皮T淋巴细胞(DETC),特异性分布在表皮组织内,在皮肤免疫监视,皮肤伤面愈合中发挥重要作用。小鼠DETC发育仅涉及胚胎14.5~18 d这一短暂时间窗,而后则不再产生这类细胞。本综述拟从DETC T细胞受体(TCR)基因重排特点及调控机制,DETC在胸腺中的阳性选择及调控机制等方面进行论述,以期对DETC发育的时空特异性有一个系统性的认识。DETC(Dendritic Epidermal T Cells)are a subset of γδ T cells,and specifically distributed in epidermal tissue.DETC play a vital role in skin immune surveillance and promote wound healing.Murine DETC only development in embryonic 14.5 day to 18 day,possessing obvious temporal specificity.As aimed to provide systemic view on spatiotemporal specificity of DETC development,this review focused on the characteristics and mechanisms of temporal specific DETC TCR rearrangement,and the features and regulatory mechanisms of positive selection of DETC.

关 键 词：树突状表皮T淋巴细胞 TCR基因 调控机制 阳性选择 

分 类 号：R392[医药卫生—免疫学]