多彩金纳米簇:从结构到生物传感和成像  

Multicolor Luminescent Gold Nanoclusters:From Structure to Biosensing and Bioimaging

作　　者：孙亚芳 周子平 舒桐 钱立生[1] 苏磊 张学记 Yafang Sun;Ziping Zhou;Tong Shu;Lisheng Qian;Lei Su;Xueji Zhang(Research Center for Biomedical and Health Science,Anhui Science and Technology University,Fengyang233100,China;Beijing Key Laboratory of Bioengineering and Sensing Technology,Research Center for Bioengineering and Sensing Technology,School of Chemistry and Biological Engineering,University of Scienceand Technology Beijing,Beijing 100083,China;Guangdong Provincial Key Laboratory of Luminescencefrom Molecular Aggregates,South China University of Technology,Guangzhou 510640,China;School of Biomedical Engineering,Shenzhen University Health Science Center,Shenzhen 518060,China)

机构地区：[1]安徽科技学院生命与健康科学学院,凤阳233100 [2]北京科技大学北京市生物工程与传感技术重点实验室生物工程与传感技术研究中心化学与生物工程学院,北京100083 [3]华南理工大学广东省分子聚集发光重点实验室,广州510640 [4]深圳大学生物医学与工程学院,深圳518060

出　　处：《化学进展》2021年第2期179-187,共9页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21904011,21890742);中央高校基本科研业务费(No.FRF-TP-19-010A3);广东省分子聚集发光重点实验室开放基金资助课题(No.2019B030301003)资助。

摘　　要：金纳米簇是一种具有发光性能的"类分子"新兴纳米材料。通过调控金原子数目和配体组成性质,金纳米簇可以实现同激发光下不同波段发射,从而展现出"五彩缤纷"的发光特性,这使其被广泛应用于光催化、光学器件、传感和成像等多个领域。因此,开发和优化具有优异发光性能的金纳米簇一直是化学、材料和生物学科的研究热点。本文立足于金纳米簇的发光色彩,根据不同发光颜色总结了相应金纳米簇的合成原理和方法,并对影响金纳米簇发光性能的因素进行了探究。同时,也总结了近年来这些"多彩"金纳米簇在生物传感和生物成像方向的应用,并对金纳米簇发展面临的挑战及发展的趋势分别进行了探讨和展望。Gold nanoclusters are a new kind of"Quasi-molecule"nanomaterials with luminescent properties.By controlling the number of gold atoms and the composition of ligands,gold nanoclusters can realize the emission of different bands under the same excitation,thus showing the"colorful"luminescence characteristics,which make them widely used in many fields such as photocatalysis,optical devices,sensing,and imaging.Therefore,the development and optimization of the synthesis method of gold nanoclusters with good fluorescence performance have been a research hotspot in the field of chemical biomaterials.In this paper,based on the luminescent color of gold nanoclusters,the synthesis principles and methods of corresponding gold nanoclusters are summarized according to different colors,and the factors affecting the luminescent properties of gold nanoclusters are explored.At the same time,the applications of these"colorful"gold nanoclusters in biosensing and bioimaging in recent years are summarized,and the challenges and development trends of gold nanoclusters are discussed and prospected respectively.

关 键 词：金纳米簇 发光 配体 生物传感 生物成像 

分 类 号：O657.3[理学—分析化学] R318.51[理学—化学]