普通冰冻血浆与新鲜冰冻血浆部分血浆组分的比较  

Comparison of Plasma Components between Frozen Plasma and Fresh Frozen Plasma

作　　者：秦冉冉 侯瑞琴[1] 杨洪燕[1] 崔银平 高雨菡 田文沁[1] 刘开彦[2] QIN Ran-Ran;HOU Rui-Qin;YANG Hong-Yan;CUI Yin-Ping;GAO Yu-Han;TIAN Wen-Qin;LIU Kai-Yan(Department of Transfusion,Peking University People's Hospital;Peking University People's Hospital,Peking University nstitute ofHematology,Beijing 100044,Chin)

机构地区：[1]北京大学人民医院输血科 [2]北京大学人民医院血液病研究所,北京100044

出　　处：《中国实验血液学杂志》2021年第2期615-619,共5页Journal of Experimental Hematology

基　　金：国家自然科学基金(31700767);北京大学人民医院研究与发展基金(RDE2019-18)。

摘　　要：目的:比较普通冰冻血浆(FP)和新鲜冰冻血浆(FFP)中血浆组分的差异。方法:随机选择北京市红十字血液中心提供的FP和FFP各20份,血浆融化后即刻分别检测凝血因子、纤溶系统及抗凝蛋白指标等12种血浆组分,即活化的部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血因子Ⅷ(FⅧ)活性、凝血因子Ⅴ(FⅤ)活性、纤维蛋白原(FIB)水平、血管性血友病因子裂解蛋白酶(ADAMTS-13)活性、血管性血友病因子(v WF)活性、D-二聚体(D-dimer,DD)、纤维蛋白降解产物(fibrin degradation products,FDP)、抗凝血酶(antithrombin,AT)、蛋白C(protein C,PC)、蛋白S(protein S,PS),并进行比较分析。结果:与FFP相比,FP中APTT明显延长(t=3.428,P<0.01),PT延长(z=-2.140,P<0.05),FⅧ活性明显降低(t=-3.372,P<0.01),但均在参考区间内;PS活性降低(t=-2.458,P<0.05);两种血浆中其余组分的差异无统计学意义(P>0.05)。结论:与FFP相比,FP缺乏某些凝血因子和抗凝蛋白,但可替代FFP应用于部分疾病的治疗。Objective:To compare the plasma components of frozen plasma(FP)and fresh frozen plasma(FFP).Methods:Twenty samples of FP and 20 samples of FFP from Beijing Red Cross Blood Center were randomly selected.Immediately after plasma melting,12 plasma components including coagulation factor,fibrinolytic system and anticoagulation protein were detected,including activated partial thromboplastin time(APTT),prothrombin time(PT),coagulation factorⅧ(FⅧ)activity,coagulation factor V(F V)activity,fibrinogen(FIB)level,ADAMTS-13 activity,von Willebrand factor(vWF)activity,D-dimer(D-dimer,DD),fibrin degradation products(FDP),antithrombin(AT),protein C(PC),and protein S(PS).All these coagulation components between the two types of plasma were compared and analyzed.Results:Compared with FFP,APTT in FP was significantly prolonged(t=3.428,P<0.01),and PT was also significantly prolonged(z=-2.140,P<0.05),and FⅧactivity was decreased(t=-3.372,P<0.01),but all in the reference range,and PS activity was decreased(t=-2.458 P<0.05),there was no statistical difference in the other part between two types of plasma(P>0.05).Conclusion:FP can substitute FFP in the treatment of some diseases,although it is lack of some coagulation factors and anticoagulation protein.

关 键 词：新鲜冰冻血浆 普通冰冻血浆 凝血因子 纤溶系统 抗凝蛋白 

分 类 号：R457.1[医药卫生—治疗学]