内质网应激与病理性血管生成相关疾病  

Endoplasmic reticulum stress and pathological angiogenesis related diseases

作　　者：蔡佳伦 刘双全[1] CAI Jialun;LIU Shuangquan(Medical Laboratory Center,the First Affiliated Hospital of University of South China,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学附属第一医院检验医学中心,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2021年第4期342-348,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81201331)。

摘　　要：血管生成是由已存在的血管在多种促血管生长因子的共同作用下产生新血管的过程,病理性血管生成除受血管内皮生长因子调控外,还与许多炎症因子、黏附分子、基质金属蛋白酶等相关。病理性血管生成在肿瘤中不仅可为肿瘤细胞提供血供和养分,还可促进肿瘤细胞向远端组织和器官转移。内质网应激是真核细胞对细胞内环境改变所做出的应激反应,轻微的内质网应激反应可引导蛋白质的正确折叠,恢复细胞内环境的稳态,然而持续性或剧烈的应激反应则会导致一系列疾病发生。内质网应激引起的血管生成主要通过激活内质网上的三个效应器:X-box结合蛋白1S、激活转录因子4和剪切后的ATF-6,这三种效应器可作用于下游促血管生成因子(如VEGF、IL-8、IL-6等),从而促进血管生成。病理性血管生成相关的疾病主要有肿瘤、动脉粥样硬化、类风湿性关节炎、糖尿病等。本文从内质网应激与病理性血管生成相关疾病的发生机制作一综述。Angiogenesis is a process in which existing blood vessels created new vessels under various vascular growth factors control.Pathological angiogenesis is not only regulated by vascular endothelial growth factor(VEGF)but also related to other factors.For instance,inflammatory factors,adhesion molecules,matrix metalloproteinases.Pathological angiogenesis for tumor cells provides the blood supply and nutrients and can help the tumor cells move to distal tissues and organs.Endoplasmic reticulum stress(ERS)is a reaction that intracellular environment change.A slight endoplasmic reticulum stress response may guide the correct protein folding,recover partitions inside the steady-state environment.However,persistent or severe stress leads to a series of diseases.Endoplasmic reticulum stress induces angiogenesis mainly through the activation of three endoplasmic reticulum effectors:X-box binding protein 1,activating transcription factor 4 and splintered activating transcription factor 6.These three effectors can act on downstream pro-angiogenic factors(such as VEGF,IL-8,IL-6,etc.)to promote angiogenesis.Pathologic angiogenesis-related diseases mainly include tumor,atherosclerosis,rheumatoid arthritis,diabetes,etc.This article summarizes the papers concerned with the pathogenic mechanism of endoplasmic reticulum stress and pathological angiogenesis.

关 键 词：血管生成 促血管生成因子 内质网应激 血管内皮生长因子 

分 类 号：R5[医药卫生—内科学]