颈动脉粥样硬化斑块内新生血管的研究现状及进展  

Research status and progress of carotid atherosclerotic intraplaque neovascularization

作　　者：齐炳才 靳琦文 胡杰[1] 邢淼 袁萌 张智鑫 董红霖[1] QI Bingcai;JIN Qiwen;HU Jie;XING Miao;YUAN Meng;ZHANG Zhixin;DONG Honglin(Department of Vascular Surgery,the Second Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China;Peking University China-Japan Friendship School of Clinical Medical,Beijing 100029,China)

机构地区：[1]山西医科大学第二医院血管外科,山西省太原市030001 [2]北京大学中日友好临床医学院,北京市100029

出　　处：《中国动脉硬化杂志》2021年第4期359-362,368,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81870354)。

摘　　要：颈动脉粥样硬化斑块破裂是导致脑卒中的重要原因之一,大量研究证实颈动脉斑块内新生血管是导致斑块内出血、斑块破裂的重要因素。炎症因子及各类细胞通过斑块内新生血管进入斑块,导致斑块稳定性破坏,但影响斑块内新生血管形成的重要相关因子和主要机制目前尚未完全明确,因此识别斑块内新生血管、探索斑块内新生血管形成的相关因子及机制是研究斑块内新生血管致斑块不稳定性的关键。抑制斑块内新生血管生成,可能成为防治颈动脉斑块破裂、降低脑栓塞事件发生的新策略。本综述旨在探讨颈动脉斑块内新生血管形成的相关因子、机制以及检测成像的最新研究进展,为动脉粥样硬化的诊疗提供支持。Rupture of carotid atherosclerotic plaque is one of the important causes of stroke.A large number of studies have confirmed that carotid plaque neovascularization is an important factor leading to intraplaque hemorrhage and rupture.Inflammatory factors and all kinds of cells enter the plaque through intraplaque neovascularization,which leads to the destruction of plaque stability.But the important related factors and main mechanisms affecting the formation of intraplaque neovascularization are not completely clear.Therefore,to identify intraplaque neovascularization and explore the related factors and mechanism of intraplaque neovascularization is the key to study plaque instability caused by intraplaque neovascularization.Inhibition of intraplaque neovascularization may be a new strategy for prevention and treatment of carotid plaque rupture and reduction of cerebral embolism.The purpose of this review is to explore the related factors,mechanism and the latest research progress of detection and imaging of carotid intraplaque neovascularization,so as to provide support for the diagnosis and treatment of clinical diseases.

关 键 词：脑卒中 颈动脉粥样硬化 易损斑块 新生血管 

分 类 号：R5[医药卫生—内科学] R654.3[医药卫生—临床医学]