补体系统在动脉粥样硬化中的作用研究进展  

A review about the role of complement system in atherosclerosis

作　　者：刘艾婷 彭旷 欧蕾宇 吴洁[1] LIU Aiting;PENG Kuang;OU Leiyu;WU Jie(Department of Cardiovascular Medicine,the First Affiliated Hospital of University of South China,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学附属第一医院心血管内科,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2021年第4期363-368,共6页Chinese Journal of Arteriosclerosis

基　　金：湖南省自然科学基金项目(2017JJ3269)。

摘　　要：炎症学说认为动脉粥样硬化(As)是由修饰的脂质颗粒与单核细胞、巨噬细胞共同参与的免疫炎症反应。补体系统作为先天性免疫的一部分,是As发生发展的重要参与者。部分补体成分在As发生发展过程中的作用有新的进展,例如,补体蛋白C1q在As中具有双重作用,即致As作用和抗As作用;补体成分C3通过与其受体结合或形成非蛋白水解中间体,参与As及晚期血栓形成;补体成分C3a与C3a受体、C5a与C5a受体1或C5a受体2结合后,通过不同途径促进核苷酸结合寡聚化结构域样受体热蛋白结构域亚家族成员3炎症小体活化、白细胞介素1β分泌,促进As发生;C5b-9补体复合物通过致动脉内皮功能障碍,从而发挥致As作用,且补体应答基因32是其关键效应因子。According to the theory of inflammation,atherosclerosis(As)is an immune inflammatory reaction involving modified lipid particles,monocytes and macrophages.As a part of innate immunity,complement system is an important player in the occurrence and development of As.There are new progress about the role of some complement components in the occurrence and development of As.Complement protein C1q plays a dual role in As,that is,inducing atherogenic and antiatherogenic effects.Complement component C3 is involved in the formation of As and late thrombosis by binding to its receptor or forming non-proteolytic intermediates.Complement component C3a binds to C3a receptor,and C5a binds to C5a receptor 1 or C5a receptor 2,which promote the activation of nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3 inflammasome and the secretion of interleukin-1βthrough different ways,and then promote the occurrence of As.C5b-9 complement complex can induce As by causing endothelial dysfunction,and response gene to complement-32 is the key effect factor.

关 键 词：补体系统 补体成分 补体受体 补体复合物 动脉粥样硬化 

分 类 号：R54[医药卫生—心血管疾病]