亚砜叶立德在C—H键活化反应中的应用研究进展  

Recent Progress on the Application of Sulfoxonium Ylides in C—H Activation

作　　者：洪超 蒋希程 于书玲 刘占祥[1] 张玉红[1,2] Hong Chao;Jiang Xicheng;Yu Shuling;Liu Zhanxiang;Zhang Yuhong(Department of Chemistry,Zhejiang University,Hangzhou 310027;State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000)

机构地区：[1]浙江大学化学系,杭州310027 [2]兰州大学功能有机分子化学国家重点实验室,兰州730000

出　　处：《有机化学》2021年第3期888-906,共19页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21672186,21472165)资助项目。

摘　　要：过渡金属催化的导向C—H键活化反应具有反应效率高、选择性好、原子经济等优点,特别是卡宾前体参与的C—H活化反应已经发展为一种新颖的构筑碳碳键的合成策略.相比于传统的重氮化合物等卡宾前体,亚砜叶立德作为一种新型的卡宾前体,具有易于制备、性质稳定、操作安全等诸多优点,被广泛应用于C—H活化反应,可以便捷地转化成各种酰甲基化或环化产物.综述了近几年来亚砜叶立德在C—H键活化反应中的应用研究进展,并对其今后的发展趋势进行了展望.Transition-metal-catalyzed chelation-assisted C—H functionalization has been increasingly explored as an efficient and atom-economical strategy for construction of C—C bonds. In particular, employing the carbene synthons as a coupling partner in C—H activation has been significantly developed. Compared with the traditional carbene precursors such as diazo compounds, sulfoxonium ylides are easier to synthesize and safer in reaction, which can be employed as practical alternatives in metal-carbene reactions. Recently, the coupling reactions of sulfoxonium ylides with organometallic intermediates, generated via C—H bond activation, have been reported. They have served as privileged synthetic skeletons to access ortho-C—H acylmethylated or cyclized compounds. The recent progress on the application of sulfoxonium ylides in C—H activation is summarized and the future research direction is prospect.

关 键 词：过渡金属 C—H活化 卡宾前体 亚砜叶立德 

分 类 号：O621.251[理学—有机化学]