铜催化羧酸与芳氨基甲酰氯的脱羧交叉偶联  

Copper-Catalyzed Decarboxylative Cross-Coupling of Carboxylic Acids and Arylcarbamoyl Chlorides

作　　者：周敦 樊爱红 李翔[1] 陈春霞[1] 孙鹏[1] 彭进松[1] Dun Zhou;Aihong Fan;Xiang Li;Chunxia Chen;Peng Sun;Jinsong Peng(College of Chemistry,Chemical Engineering and Resource Utilization,Northeast Forestry University,Harbin 150040)

机构地区：[1]东北林业大学化学化工与资源利用学院,哈尔滨150040

出　　处：《有机化学》2021年第3期1146-1152,共7页Chinese Journal of Organic Chemistry

基　　金：中央高校基本科研业务费专项资金(Nos.2572019CG06,2572020DR07);黑龙江省自然科学基金(Nos.LC2018003,B2017002);高等学校学科创新引智计划(111计划,No.B20088)资助项目。

摘　　要：报道了在不加碱的条件下,无配体铜盐能有效催化羧酸和氨基甲酰氯脱羧交叉偶联反应,以CuCl_(2)为催化剂、苯为溶剂,于120℃条件下反应48h即可实现脱羧交叉偶联过程.在此标准条件下,该催化体系对官能团普适性较好,以较高收率获得了各种酰胺,产物经^(1)H NMR、^(13)CNMR和HRMS表征.A ligand-free copper-catalyzed decarboxylative cross-coupling reaction of carboxylic acids and carbamoyl chlorides in the absence of base was developed. With CuCl_(2) as the catalyst, the decarboxylative cross-coupling process could be realized in benzene at 120 ℃ in 48 h. Under the standard condition, the catalytic system had good functional group tolerance, and diverse amides were obtained in good to high yields. The structures of products were elucidated by ^(1)H NMR, ^(13)C NMR and HRMS spectra.

关 键 词：铜催化 脱羧交叉偶联 碳-碳成键 芳氨基甲酰氯 酰胺 

分 类 号：O621.251[理学—有机化学]