金鸡纳硅醚衍生物有机催化吲哚与靛红的不对称Friedel-Crafts反应  

Enantioselective Friedel-Crafts Reaction of Indoles with Isatins Catalyzed by Cinchona Alkaloid Silyl Ether Derivative

作　　者：张俊伟 吴昊 张伟鑫 王黎明 金瑛 Junwei Zhang;Hao Wu;Weixin Zhang;Liming Wang;Ying Jin(Department of Pharmacy,Jilin Medical University,Jilin,Jilin 132013;Department of Pharmacy,Yanbian University,Yanjin,Jilin 133000)

机构地区：[1]吉林医药学院药学院,吉林吉林132013 [2]延边大学药学院,吉林延吉133000

出　　处：《有机化学》2021年第3期1187-1192,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21102055);吉林省自然科学基金(No.20190201077JC);吉林省卫生厅技术创新项目(No.2020J074);国家大学生创新创业训练计划(No.201913706058)资助项目。

摘　　要：金鸡纳硅醚衍生物用于有机催化不同吲哚和靛红的不对称Friedel-Crafts反应.筛选出最佳的催化剂体系,以78%~96%的产率和最高达99%的对映选择性获得了手性3-羟基-2-吲哚酮.拓宽了该反应的催化剂类型和底物范围.A series of cinchona alkaloid silyl ether derivatives have been used to catalyze the enantioselective Friedel-Crafts reaction of indoles with isatins.The resulting 3-hydroxy-2-oxindoles were obtained in good yields(78%~96%)with high enantioselectivities(up to 99%ee).The catalyst type and the substrate scope were broadened in this methodology.

关 键 词：金鸡纳硅醚衍生物 有机催化 靛红 吲哚 不对称Friedel-Crafts反应 

分 类 号：O621.251[理学—有机化学]