原人参三醇生物活性及其作用机制研究进展  

Research Progress on the Biological Activity and Mechanism of Protopanaxatriol

作　　者：陈小玲 史大臻 司函瑞 刘金平[1] 李平亚[1] CHEN Xiaoling;SHI Dazhen;SI Hanrui;LIU Jinping;LI Pingya(College of Pharmacy,Jilin University,Changchun 130021,Jilin,China)

机构地区：[1]吉林大学药学院,吉林长春130021

出　　处：《辽宁中医药大学学报》2021年第2期209-214,共6页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：原人参三醇(protopanaxatriol,PPT)是人参皂苷Rg1的代谢产物,其结构特征是C-6位具有羟基,属于达玛烷型皂苷元。大量的研究表明,PPT具有较好的心血管保护作用、神经系统作用、抗炎作用、抗脂肪合成、抗糖尿病和其他的生物活性。该文通过检索与PPT相关的文献,就PPT的生物活性及其作用机制进行了总结和归纳,以期为PPT的进一步开发和利用提供一定的理论基础。Protopanaxatriol(PPT)is a metabolite of ginsenoside Rg1,a kind of dammaranetype aglycon with a hydroxyl group at the C-6 position. A great number of studies have indicated that protopanaxatriol has good biological activities,such as cardiovascular protection,nervous system function,anti-inflammatory,anti-lipid synthesis,anti-diabetes,anti-tumor and other biological activities. This article summarizes the biological activity and its mechanism of PPT by searching the literature related to PPT so as to provide a certain theoretical basis for the further development and utilization of PPT.

关 键 词：原人参三醇 生物活性 作用机制 

分 类 号：R284[医药卫生—中药学]