湖南地区中青年人群正常体质代谢异常和代谢正常肥胖表型的流行病学及生活方式危险因素研究  

Epidemiological and lifestyle risk factors of metabolic obesity normal weight and metabolic healthy obesity phenotypes in Chinese young and middle-aged people

作　　者：钟志远 刘心瑶[1] 杨袆萍 陆瑶[1] 袁洪[1] ZHONG Zhiyuan;LIU Xinyao;YANG Weiping;LU Yao;YUAN Hong(Department of Pharmacy,the Third Xiangya Hospital,Central South University,Changsha,Hunan 410013,China)

机构地区：[1]中南大学湘雅三医院临床药理中心,湖南省长沙市410013

出　　处：《中国动脉硬化杂志》2021年第5期433-439,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81770403);国家重点研发计划项目子课题(2016YFC0900802、2018YFC1311302);国家重点研发计划项目(2019YFF0216300)。

摘　　要：目的确定中青年人群中各种体质量代谢表型的患病率,尤其是正常体质代谢异常(MONW)和代谢正常肥胖(MHO)这两种特殊表型,并调查各表型相关的人口统计学和行为学因素。方法以中南大学湘雅三医院健康管理中心44551例中青年(30~59岁)体检人群为研究对象,根据体质量和代谢状态将人群分为四种表型:正常体质代谢正常(MHNW)、正常体质代谢异常(MONW)、代谢正常肥胖(MHO)和代谢异常肥胖(MAO)。收集一般资料,进行体格检查及生化指标检测;采用Logistic回归分析评估生活方式因素与正常体质代谢异常和代谢正常肥胖表型的相关性。结果正常体质代谢正常、正常体质代谢异常、代谢正常肥胖、代谢异常肥胖表型在中青年人群中的患病率分别为58.0%、6.4%(占正常体质人群的10.0%)、18.0%和17.6%。多元Logistic回归分析结果显示,在校正了年龄、文化程度后,男性正常体质代谢异常表型与吸烟(OR=1.12,95%CI:1.02~1.24)、饮酒(OR=1.22,95%CI:1.11~1.35)呈正相关,与健康的饮食习惯(OR=0.88,95%CI:0.80~0.98)呈负相关。而女性正常体质代谢异常表型与中高度体育锻炼(OR=0.83,95%CI:0.73~0.93)和健康饮食习惯(OR=0.80,95%CI:0.71~0.90)呈负相关。结论在中青年人群中,正常体质代谢异常表型患病率为6.4%,约占正常体质人群的10.0%,代谢正常肥胖表型患病率为18.0%,约占肥胖人群的一半。代谢表型在不同性别的中青年人群之间具有不同的临床特征。为了预防体质量正常人群出现代谢异常,应多锻炼身体,健康饮食,尤其是男性还应该戒烟、戒酒。Aim To determine the prevalence of various body weight metabolic phenotypes in the young and middle-aged population,especially metabolic obesity normal weight(MONW)and metabolic healthy obesity(MHO),and investigate the demographic and behavioral factors related to each phenotype.Methods Taking 44551 young and middle-aged(30~59 years old)physical examination population from the Health Management Center of the Third Xiangya Hospital of Central South University as the research object,the population was divided into four phenotypes according to body weight and metabolic status:metabolic healthy normal weight(MHNW),MONW,MHO,and metabolic abnormal o besity(MAO).General data were collected,physical examination and biochemical index detection were performed;L ogistic regression analysis was used to evaluate the correlation between lifestyle factors and MONW,MHO phenotypes.Results The prevalence of MHNW,MONW,MHO and MAO phenotypes in the young and middle-aged population were 58.0%,6.4%(accounting for 10.0%of the normal population),18.0%and 17.6%,respectively.The results of multivariate Logistic regression analysis showed that after adjusting for age and educational level,the MONW phenotype in man was positively correlated with smoking(OR=1.12,95%CI:1.02~1.24),drinking(OR=1.22,95%CI:1.11~1.35),was negatively correlated with healthy eating habits(OR=0.88,95%CI:0.80~0.98).The MONW phenotype in women was negatively correlated with medium and high physical exercise(OR=0.83,95%CI:0.73~0.93)and healthy eating habits(OR=0.80,95%CI:0.71~0.90).Conclusion Among the young and middle-aged population,the prevalence rate of MONW phenotype is 6.4%,which accounts for about 10.0%of the normal constitution population,and the prevalence rate of MHO phenotype is 18.0%,which accounts for about half of the obese population.M etabolic phenotypes have different clinical characteristics among young and middle-aged people of different genders.In order to prevent metabolic abnormalities in people with normal body mass,they should exercise more and e

关 键 词：正常体质代谢异常 代谢正常肥胖 代谢综合征 肥胖 生活方式 

分 类 号：R589[医药卫生—内分泌]