The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis  

作　　者：Lu Li An Tong Qiangsheng Zhang Yuquan Wei Xiawei Wei 

机构地区：[1]Laboratory of Aging Research and Cancer Drug Target,State Key Laboratory of Biotherapy and Cancer Center,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu 610041,China [2]Department of Gynecology and Obstetrics,Development and Related Disease of Women and Children Key Laboratory of Sichuan Province,Key Laboratory of Birth Defects and Related Diseases of Women and Children,Ministry of Education,West China Second Hospital,and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Journal of Molecular Cell Biology》2021年第1期3-14,共12页分子细胞生物学报（英文版）

基　　金：This work was supported by the National Major Scientific and Technological Special Project for‘Significant New Drugs Development’(2018ZX09733001);the National Key Research and Development Program of China(2016YFA0201402);and National Natural Science Foundation Regional Irmovation and Development(U19A2003).;The authors would like to thank Wen Nie and Min Luo for their assistance with the manuscript preparation.

摘　　要：Necrosis,a type of unwanted and passive cell demise,usually occurs under the excessive external stress and is considered to be unregulated.However,under some special conditions such as caspase inhibition,necrosis is regulable in a well-orchestrated way.The term'regulated necrosis'has been proposed to describe such programed necrosis.Recently,several forms of necrosis,including necroptosis,pyroptosis,ferroptosis,parthanatos,oxytosis,NETosis,and Na^(+)/K^(+)ATPasimediated necrosis,have been identified,and some crucial regulators governing regulated necrosis have also been discovered.Mixed lineage kinase domain-like pseudokinase(MLKL),a core regulator in necroptosis,acts as an executioner in response to ligands of death receptor family.Its activation requires the receptor-interacting protein kinases,RIP1 and RIP3.However,MLKL is only involved in necroptosis,i.e.MLKL is dispensable for necrosis.Therefore,this review is aimed at summarizing the molecular mechanisms of MLKLdependent and MLKL-independent necrosis.

关 键 词：MLKL NECROSIS NECROPTOSIS MECHANISM DISEASES 

分 类 号：Q255[生物学—细胞生物学]