鼠进行性强直蛋白人类同源物与骨、关节疾病  

Research Advances of Human Homologue of Mouse Progressive Ankylosis Protein and Bone and Joint Diseases

作　　者：于鹏[1,2] 翁习生[2] YU Peng;WENG Xisheng(Department of International Medical Service,;Department of Orthopaedics,PUMC Hospital,CAMS and PUMC,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院国际医疗部,北京100730 [2]中国医学科学院,北京协和医学院,北京协和医院骨科,北京100730

出　　处：《中国医学科学院学报》2021年第2期293-299,共7页Acta Academiae Medicinae Sinicae

摘　　要：鼠进行性强直蛋白人类同源物是一种无机焦磷酸转运调节蛋白,通过调节无机焦磷酸水平调控组织矿化,因而在强直性脊柱炎、颅骨干骺端发育不全、关节软骨钙化等骨关节疾病的发病、进展机制中发挥重要作用。本文总结ANKH和上述骨关节疾病的研究进展。The human homologue of mouse progressive ankylosis protein(ANKH)is an inorganic pyrophosphate transport regulator,which regulates tissue mineralization by controlling the level of inorganic pyrophosphate.It plays an important role in the pathogenesis and development of bone and joint diseases,such as ankylosing spondylitis,craniometaphyseal dysplasia,and articular cartilage calcification.This review summarizes the progress of research on ANKH and the above-mentioned diseases.

关 键 词：鼠进行性强直蛋白人类同源物 颅骨干骺端发育不全 关节软骨钙化 焦磷酸钙晶体沉积 

分 类 号：R684[医药卫生—骨科学]