选择性溶剂提取—旋光法测定薄荷油-β-环糊精包合物油利用率  

Determination of oil utilization ratio of peppermint oil-β-cyclodextrin inclusion compound by selective solvent extraction-polarimetry method

作　　者：陈恺悦 闫福鹏 王家雯 邵欣怡 李菲 CHEN Kai-yue;YAN Fu-peng;WANG Jia-wen;SHAO Xin-yi;LI Fei(Shandong First Medical University&Shandong Academy of Medical Sciences,Tai an 271016,China)

机构地区：[1]山东第一医科大学(山东省医学科学院)药学院,山东泰安271016 [2]山东第一医科大学(山东省医学科学院),山东泰安271016

出　　处：《泰山医学院学报》2021年第4期246-248,共3页Journal of Taishan Medical College

基　　金：国家级大学生创新创业训练计划项目(201910439010);中华医学会医学教育分会和中国高等教育学会医学教育研究项目(2018B-N19003)。

摘　　要：目的建立选择性溶剂提取—旋光法测定薄荷油-β-环糊精包合物油利用率的方法。方法采用无水乙醇为选择性溶剂,选择性提取包合物中的薄荷油,旋光法测定薄荷油的含量,并与水蒸气蒸馏法测定薄荷油-β-环糊精包合物油利用率进行比较。结果选择性溶剂提取—旋光法标准曲线线性范围为20~640 mg·ml^(-1)(r=0.9997),平均加样回收率大于95%,RSD<2%。结论该方法快速、准确,可用于测定薄荷油-β-环糊精包合物油利用率。Objective:To establish a selective solvent extraction-polarimetry method for determination of oil utilization ratio of peppermint oil-β-cyclodextrin inclusion compound.Methods:Peppermint oil in the compound was extracted using absolute alcohol as the selective solvent and was determined by polarimetry method.The results of both selective solvent extraction-polarimetry and steam distillation method were compared.Results:The utilization ratio of oil was successfully determined by selective solvent extraction-polarimetry method,the linear range was 20~640 mg﹒ml^(-1)(r=0.9997),and the recovery was higher than 95%(RSD<2%).Conclusion:Selective solvent extraction-polarimetry method is rapid and accurate,and can be used to determine the oil utilization ratio of peppermint oil-β-cyclodextrin inclusion compound.

关 键 词：薄荷油 包合物 旋光法 选择性溶剂 

分 类 号：R917[医药卫生—药物分析学]