六味地黄丸改善骨质疏松性疼痛及骨代谢状态的临床研究  

Clinical study on the effect of Liuwei Dihuang Pill on the pain symptom and bone metabolism in osteoporosis

作　　者：徐栋 XU Dong(Dept.of Orthopaedics,First People's Hospital of Ningyang County,271400 China)

机构地区：[1]宁阳县第一人民医院骨科,山东宁阳271400

出　　处：《泰山医学院学报》2021年第4期301-304,共4页Journal of Taishan Medical College

摘　　要：目的探讨六味地黄丸缓解更年期骨质疏松性疼痛以及改善骨质代谢的临床效果。方法选择80例女性更年期骨质疏松症患者,随机数字表法分为观察组(n=40)和对照组(n=40),对照组连续口服碳酸钙片+维生素AD治疗,治疗组在对照组治疗的基础上加服六味地黄丸,两组疗程均为3个月,观察两组患者的视觉模拟疼痛评分(VAS)、数字疼痛评分(NRS)、下腰功能评分(JOA)和Oswestry功能障碍评分(ODI)的变化,以及患者骨质代谢相关指标的差异,包括骨密度(BMD)、血钙(Ca)、血磷(P)。结果治疗前,两组患者的疼痛评分及骨代谢指标比较差异无统计学意义(P>0.05)。治疗3个月后,两组VAS、NRS、JOA、ODI评分均有降低,但是治疗组评分改善的程度明显高于对照组,差异具有统计学意义(P<0.001)。两组患者的BMD、血Ca水平均有改善,但治疗组改善程度明显高于对照组,差异具有统计学意义(P<0.001)。结论六味地黄丸能有效改善更年期骨质疏松性疼痛的临床症状,并通过改善骨质代谢来降低骨质疏松程度,具有良好的临床疗效,值得进一步研究和推广。Objective:To investigate the clinical effect of Liuwei Dihuang Pill on relieving menopausal osteoporosis pain and improving bone metabolism.Methods:Eighty cases of women with menopausal osteoporosis were chosen and divided into observation group(n=40)and the control group(n=40)by random number table method,control group received continuous oral calcium carbonate+vitamin AD treatment,while the treatment group also had bolus of Liuwei Dihuang Pill on the basis of control group therapy,and the course was 3 months.Visual analog pain score(VAS),digital pain score(NRS),low back function score(JOA),Oswestry disability scale(ODI)changes and the differences of bone metabolism including mineral density(BMD),blood calcium(Ca),blood phosphorus(P)in patients of the two groups were observed.Results:Before treatment,there was no significant difference in pain score and bone metabolism between the two groups(P>0.05).After 3 months of treatment,VAS,NRS,JOA and ODI scores in both groups were reduced,but the improvement of scores in the treatment group was significantly higher than that in the control group,with statistically significant difference(P<0.001).BMD,blood Ca levels in both groups were improved,while the improvement in the treatment group was significantly higher than that in the control group,and the difference was statistically significant(P<0.001).Conclusion:Liuwei Dihuang Pill can effectively improve the clinical symptoms of menopausal osteoporosis pain,and reduce osteoporosis by improving bone metabolism,which has a good clinical effect and is worthy of further study and promotion.

关 键 词：更年期骨质疏松 六味地黄丸 疼痛 骨代谢 

分 类 号：R681[医药卫生—骨科学]