短时多次蓝光照射联合酪酸梭菌二联活菌、茵陈胃苓退黄合剂对新生儿高胆红素血症疗效及免疫功能的影响  

Therapeutic efficacy of short-term multiple blue light irradiations combined with clostridium butyricum double live germs and Yinchen Weiling Tuihuang Mixture on neonatal hyperbilirubinemia patients and its impact on the immune function

作　　者：徐杨 田云龙 李年华[1] XU Yang;TIAN Yunlong;LI Nianhua(Department of Pediatrics,Taizhou Hospital of Traditional Chinese Medicine,Jiangsu Province,Jiangsu,Taizhou 225300,China)

机构地区：[1]江苏省泰州市中医院儿科,江苏泰州225300

出　　处：《中国医药科学》2021年第7期20-24,共5页China Medicine And Pharmacy

摘　　要：目的对新生儿高胆红素血症患儿予以短时多次蓝光照射联合酪酸梭菌二联活菌、茵陈胃苓退黄合剂治疗,观察有效性、安全性以及对于免疫功能的影响,探讨最佳治疗措施,裨益临床。方法选择江苏省泰州市中医院儿科2019年1月至2020年1月收治的200例新生儿高胆红素血症患儿,按照随机数字表法分为两组,每组各100例,观察组予以短时多次蓝光照射联合酪酸梭菌二联活菌、茵陈胃苓退黄合剂治疗,对照组给予短时多次蓝光照射联合酪酸梭菌二联活菌治疗。在治疗前、后5 d采用经皮胆红素检测仪检测经皮胆红素,全自动生化分析仪检测总胆红素(TBIL);采用酶联免疫吸附法测定免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM);采用新生儿行为神经评定量表(NBNA)测定神经功能。同时对两组患儿的疗效、黄疸消退时间及治疗期间的不良反应情况进行比较分析。结果治疗前,两组患者的经皮胆红素、TBIL水平、免疫功能指标及神经功能评分比较,差异均无统计学意义(P>0.05);治疗后,观察组的经皮胆红素、TBIL水平低于对照组,IgG、IgA、IgM以及神经功能评分水平高于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,黄疸消退时间短于对照组、不良反应发生率低于对照组,差异均有统计学意义(P<0.05)。结论对新生儿高胆红素血症予以短时多次蓝光照射联合酪酸梭菌二联活菌、茵陈胃苓退黄合剂,可较好的改善血液指标、免疫功能及神经功能,提高疗效,具有较高安全性。Objective To treat neonatal hyperbilirubinemia patients with short-term multiple blue light irradiations combined with clostridium butyricum double live germs and Yinchen Weiling Tuihuang Mixture,to observe the efficacy,safety and its impact on the immune function,and to investigate the best treatment measures,so as to benefit the clinic.Methods A total of 200 cases of neonatal hyperbilirubinemia patients admitted to Taizhou Hospital of Traditional Chinese Medicine from January 2019 to January 2020 were selected and divided into the observation group(n=100)and the control group(n=100)according to the random number table method.The observation group was treated with short-term multiple blue light irradiations combined with clostridium butyricum double live germs and Yinchen Weiling Tuihuang Mixture,while the control group was treated with short-term multiple blue light irradiations combined with clostridium butyricum double live germs.Before and 5 days after treatment,the percutaneous bilirubin was detected by percutaneous bilirubin detector,total bilirubin(TBIL)was detected by automatic biochemical analyzer,immunoglobulin G(IgG),immunoglobulin A(IgA)and immunoglobulin M(IgM)were determined by enzyme-linked immunosorbent assay,and the neurological function was detected by neonatal behavioral neurological assessment(NBNA).At the same time,the therapeutic efficacy,jaundice regression time and adverse reactions(ADRs)during treatment were compared and analyzed between children in the two groups.Results Before treatment,there were no significant differences in the percutaneous bilirubin level,TBIL level,immune function index and neurological function score between children in the two groups(P>0.05).After treatment,the levels of percutaneous bilirubin and Tbil in the observation group were lower than those in the control group,while the levels of IgG,IgA,IgM and neurological function score were higher than those in the control group,with statistically significant differences(P<0.05).The total efficacy rate of the observ

关 键 词：新生儿高胆红素血症 蓝光照射 酪酸梭菌二联活菌 中药 免疫功能 

分 类 号：R722.17[医药卫生—儿科]